Browsing Faculty of Health Sciences by Issue Date
Now showing items 1-20 of 2368
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Variable-temperature X-ray powder diffraction analysis of the crystal transformation of the pharmaceutically preferred polymorph C of mebendazole
(Elsevier, 2005)Mebendazole is a common benzimidazole anthelmintic that is water insoluble. It is reported to exist in three different polymorphic forms in the solid state, i.e. polymorph A, B and C. Form C is the pharmaceutically preferred ... -
Synthesis and transdermal properties of acetylsalicylic acid and selected esters
(Elsevier, 2006)The primary aim of this study was to determine the transdermal penetration of acetylsalicylic acid and some of its derivatives, to establish a correlation, if any, with selected physicochemical properties and to determine ... -
Effect of penetration modifiers on the dermal and transdermal delivery of drugs and cosmetic active ingredients
(Karger, 2008)In this study the effect of 2 penetration modifiers, dimethyl isosorbide (DMI) and diethylene glycol monoethyl ether (DGME) on the skin delivery of hydroquinone (HQ), salicylic acid (SA) and octadecenedioic acid (DIOIC) ... -
Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder
(Elsevier, 2008)Stereotypy is an important manifestation of obsessive compulsive disorder (OCD). OCD involves disturbed serotonin and dopamine pathways, and demonstrates a selective response to serotonin reuptake inhibitors (SRI), with ... -
Die invloed van fisieke-aktiwiteitsdeelname op die verband tussen die koronêrerisiko-indeks en enkele demografiese konstrukte by NG-predikante in Suid-Afrika
(University of South Africa, the Department of Practical theology, 2008)The objective of this study was to determine the interaction of physical activity on the relationship between coronary risk index and years of service, congregation size, co-ministership and congregation type of Dutch ... -
Studies on cellular resilience and adaptation following acute and repetitive exposure to ozone in cultured human epithelial (HeLa) cells
(Taylor & Francis, 2008)Ozone is used to treat several medical conditions, while the underlying mechanisms of action are sometimes poorly understood. In the current study, we exposed cultured human epithelial (HeLa) cells acutely and repeatedly ... -
Prevalence of drug-drug interactions of antiretroviral agents in the private health care sector in South Africa
(Health & Medical Publishing Group, 2008)Objectives. Human immunodefiency virus (HIV) infection can be effectively treated with highly active antiretroviral therapy (HAART), requiring concomitant administration of three to four different agents, often with a ... -
'n Oorsigartikel oor tipes gesinsrituele en die simboliese betekenis daarvan vir jong vowassenes
(Suid-Afrika Akademie Wetenskap en Kuns, 2008) -
The psychological implications of the closing of a mine for workers and their families
(National Association of Social Workers, 2008) -
Expressive art in cross-cultural group supervision: applying the Mmogo-method
(Elliott & Fitzpatrick, 2008) -
DNA damage and repair detected by the comet assay in lymphocytes of African petrol attendants: a pilot study
(Oxford Univ Press, 2008)Petrol attendants are exposed to petrol volatile organic compounds (VOCs) which may have genotoxic and carcinogenic effects. The single-cell gel electrophoresis assay (comet assay) is a method highly sensitive to DNA damage ... -
The Von Willebrand factor as marker of vascular function in South African women
(Oxford Univ Press, 2008)BACKGROUND: The increasing prevalence of hypertension and vascular-related morbidity and mortality among Africans emphasizes the need to identify markers for the early detection of vascular disease. Caucasian-based ... -
Dual inhibition of monoamine oxidase B and antagonism of the adenosine A2A receptor by (E,E)-8-(4phenylbytadien-1-yl) caffeine analogues
(Elsevier, 2008)The adenosine A2A receptor has emerged as an attractive target for the treatment of Parkinson’s disease (PD). Evidence suggests that antagonists of the A2A receptor (A2A antagonists) may be neuroprotective and may help to ... -
Deuterium isotope effects for the oxidation of 1-methyl-3phenyl-3pyrrolinyl analogues by monoamine oxidase B
(Elsevier, 2008)The parkinsonian inducing agent, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is a cyclic tertiary allylamine exhibiting good monoamine oxidase B (MAO-B) substrate properties. MAO-B catalyzes the ring α-carbon ... -
Coping with urbanization: a cardiometabolic risk? The THUSA study
(Elsevier, 2008)An assessment of specific coping styles in rural-urban Africans is done to evaluate its contribution as cardiometabolic risk factor. In total, 608 apparently healthy Africans were included in a cross-sectional comparative ... -
Stress and re-stress increases conditioned taste aversion learning in rats: possible frontal cortical and hippocampal muscarinic receptor involvement
(Elsevier, 2008)Symptoms of posttraumatic stress disorder are often precipitated by sensory cues in the form of visual, auditory, olfactory and gustatory “flashbacks” resulting in enhanced fear-memory consolidation and the characteristic ... -
Genetic polymorphisms of beta(2)- and beta(3)- adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women
(Thieme, 2008)Background: Genetic variation in the β2 (ADRB2) and β3 (ADRB3) adrenergic receptor genes are associated with obesity and insulin resistance. To further elucidate the role of these genes in the pathophysiology of obesity ... -
Development of microporous drug-releasing films cast from artificial nanosized latexes of poly (styrebe-co-methyl methacrylate) or poly (styrene-co-ethyl methacylate)
(Elsevier, 2008)Two sets of copolymers comprising of styrene and either methyl or ethyl methacrylate as comonomer were conveniently synthesized by microemulsion copolymerization. The purified materials were characterized by GPC-MALLS and ... -
Hyperuricaemia is an independent factor for the metabolic syndrome in a sub-Saharan African population: a factor analysis
(Elsevier, 2008)Objective To assess the risk factor pattern of the metabolic syndrome and its association with insulin resistance and hyperuricaemia in a sub-Saharan African population with different levels of urbanisation. Methods Four ... -
Investigating the potential neuroprotective effects of statins on DNA damage in mouse striatium
(Elsevier, 2008)We investigated the protective effect of pravastatin, simvastatin and atorvastatin on striatal DNA damage as a potential method to conserve and protect the nigrostriatal neurons. C57Bl/J6 mice were treated with combinations ...
