Browsing Faculty of Health Sciences by Subject "Permeability"

Now showing items 1-4 of 4

    • Breaching the skin barrier through temperature modulations 

      Shahzad, Yasser; Louw, Ruaan; Gerber, Minja; Du Plessis, Jeanetta (Elsevier, 2015)
      The impermeability of the stratum corneum often hinders the transport of molecules across the skin. Temperature modulations in the skin and the application of local heat both have the potential of circumventing this problem ...

    • The influence of pH on the in vitro permeation of rhodium through human skin 

      Jansen van Rensburg, Sané; Franken, Anja; Du Plessis, Jeanetta; Du Plessis, Johannes Lodewykus (Sage, 2017)
      Workers in precious metals refineries are at risk of exposure to salt compounds of the platinum group metals through inhalation, as well as through the skin. Rhodium salt permeation through the skin has previously been ...

    • Poly(amidoamine) dendrimers as a pharmaceutical excipient. Are we there yet? 

      Otto, Daniel P.; De Villiers, Melgardt M. (Elsevier, 2018)
      Drug solubility could affect the therapeutic use of a drug because the biological activity of a drug is only possible if some fraction of a dissolved drug can permeate and overcome biological membranes to reach its site ...

    • Vesicular carriers for skin drug delivery: the Pheroid™ technology 

      Kilian, Dewald; Shahzad, Yasser; Fox, Lizelle; Gerber, Minja; Du Plessis, Jeanetta (Bentham Science, 2015)
      The skin remains an attractive area for drug delivery. The skin, however, often limits the ingress of drugs, because of its very low permeability. Much research, focusing on employing a variety of physical and chemical ...