Browsing Faculty of Health Sciences by Subject "2-Aminopyrimidine"

Now showing items 1-2 of 2

    • 2-Aminopyrimidines as dual adenosine A1/A2A antagonists 

      Robinson, Sarel J.; Petzer, Jacobus P.; Terre'Blanche, Gisella; Petzer, Anél; Van der Walt, Mietha M.; Bergh, Jacobus J.; Lourens, Anna C.U. (Elsevier, 2015)
      In this study thirteen 2-aminopyrimidine derivatives were synthesised and screened as potential antagonists of adenosine A1 and A2A receptors in order to further investigate the structure activity relationships of this ...

    • Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists 

      Robinson, Sarel J.; Petzer, Jacobus P.; Terre'Blanche, Gisella; Petzer, Anél; Lourens, Anna C.U.; Rousseau, Amanda L. (Elsevier, 2016)
      A novel series of carbamate substituted 2-amino-4,6-diphenylpyrimidines was evaluated as potential dual adenosine A1 and A2A receptor antagonists. The majority of the synthesised compounds exhibited promising dual affinities, ...