Now showing items 1-4 of 4

    • Absorptive and secretory transport of selected artemisinin derivatives across Caco-2 cell monolayers 

      Heyns, Jaco; Willers, Clarissa; Haynes, Richard K.; Wong, Ho N.; Hamman, Josias; Gouws, Chrisna (Bentham Science, 2018)
      Background: Malaria continues to be a major health concern and affects more than 200 million people a year. Drugs currently used for treatment of malaria are increasingly rendered ineffectual by the ongoing emergence of ...
    • Herb-drug pharmacokinetic interactions: transport and metabolism of indinavir in the presence of selected herbal products 

      Calitz, Carlemi; Gouws, Chrisna; Viljoen, Joe; Steenekamp, Jan; Hamman, Josias (MDPI, 2015)
      Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions ...
    • In vitro drug permeation enhancement potential of aloe gel materials 

      Lebitsa, Tebogo; Hamman, Josias; Lu, Zhilei; Viljoen, Alvaro; Lebitsa, Tebogo; Hamman, Josias; Lu, Zhilei; Viljoen, Alvaro (Bentham Science, 2012)
      Aloe vera gel previously showed the ability to increase the bioavailability of vitamins and to enhance the in vitro transport of a macromolecular drug across intestinal epithelial cell monolayers. The purpose of this study ...
    • Permeation of PLGA nanoparticles across different in vitro models 

      Nkabinde, Lindiwe A.; Hamman, Josias H.; Shoba-Zikhali, Lungile N.N.; Semete-Makokotlela, Boitumelo; Kalombo, Lonji; Nkabinde, Lindiwe A.; Hamman, Josias H.; Shoba-Zikhali, Lungile N.N.; Semete-Makokotlela, Boitumelo; Kalombo, Lonji (Bentham Science, 2012)
      Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance ...