Browsing Faculty of Health Sciences by Author "Huisman, H.W."
Now showing items 1-17 of 17
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8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA study
Mels, C.M.C.; Schutte, A.E.; Schutte, R.; Pretorius, P.J.; Smith, W.; Huisman, H.W.; Van der Westhuizen, F.H.; Fourie, C.M.T.; Van Rooyen, J.M.; Kruger, R.; Louw, R.; Malan, N.T.; Malan, L. (Taylor & Francis, 2014)Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study ... -
Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study
Kruger, R.; Schutte, R.; Huisman, H.W.; Van Rooyen, J.M.; Malan, N.T.; Fourie, C.M.T.; Louw, R.; Van der Westhuizen, F.H.; Van Deventer, C.A.; Malan, L.; Schutte, A.E. (Springer Nature, 2012)Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory ... -
Carotid characteristics of Africans with five-year sustained hypertension
Maritz, M.; Fourie, C.M.T.; Van Rooyen, J.M.; Huisman, H.W.; Schutte, A.E. (Clinics Cardive Publ Pty Ltd, 2016)Introduction: An important feature of hypertension is a reduction in large artery distensibility, which may be due to structural and functional adaptations. Black populations are particularly prone to the development of ... -
Chronic distress and acute vascular stress responses associated with ambulatory blood pressure in low-testosterone African men: the SABPA Study
Malan, N.T.; Hamer, M.; Schutte, A.E.; Huisman, H.W.; Schutte, R.; Smith, W.; Mels, C.M.C.; Van Rooyen, J.M.; Malan, L. (Nature Publishing Group, 2014)It is known that low testosterone (T) and high cortisol levels are associated with hypertension as well as with chronic stress, linking stress with elevated blood pressure (BP). However, the association between acute ... -
Classifying Africans with the Metabolic Syndrome
Schutte, A.E.; Schutte, R.; Huisman, H.W.; Van Rooyen, J.M.; Malan, L.; Olckers, A.; Malan, N.T. (Thieme, 2009)This study was aimed to compare prevalences of the metabolic syndrome in Africans using five definitions as proposed by the World Health Organization (WHO), the European Group for the Study of Insulin Resistance (EGIR), ... -
A comparison of the association between glomerular filtration and L-arginine status in HIV-infected and uninfected African men: the SAfrEIC study
Glyn, M.C.; Van Rooyen, J.M.; Schutte, R.; Huisman, H.W.; Mels, C.M.C.; Schutte, A.E. (Nature Publishing Group, 2013)Hypertension, a major risk factor for cardiovascular disease worldwide, is increasing significantly in urbanised South Africans. Impaired glomerular filtration is a potential contributor to hypertension. Although HIV ... -
Compromised bioavailable IGF-1 of black men relates favourably to ambulatory blood pressure: the SABPA study
Schutte, A.E.; Schutte, R.; Smith, W.; Huisman, H.W.; Mels, C.M.C.; Malan, L.; Fourie, C.M.T.; Malan, N.T.; Van Rooyen, J.M.; Kruger, R. (Elsevier, 2014)Objectives Insulin-like growth factor-1 (IGF-1) has potent endothelial-protective, anti-platelet and anti-thrombotic activities, and also exerts mitogenic and proliferatory actions on vascular smooth muscle cells. Conflicting ... -
Conventional and behavioral risk factors explain differences in sub-clinical vascular disease between black and Caucasian South Africans: the SABPA study
Hamer, M.; Malan, L.; Schutte, A.E.; Huisman, H.W.; Van Rooyen, J.M.; Schutte, Rudolph; Fourie, C.M.T.; Malan, N.T.; Seedat, Y.K. (Elsevier, 2011)Conventional and behavioral risk factors explain differences in sub-clinical vascular disease between black and Caucasian South Africans: The SABPA study Objectives: There is an emerging burden of cardiovascular disease ... -
Ethnicity-specific differences in L-arginine status in South African men
Glyn, M.C.; Van Rooyen, J.M.; Schutte, R.; Huisman, H.W.; Fourie, C.M.T.; Smith, W.; Malan, L.; Malan, N.T.; Mels, C.M.C.; Schutte, A.E. (Nature Publishing Group, 2012)The aetiology for an increasing incidence of hypertensive cardiovascular disease amongst Africans in southern Africa is unclear. Hypertension may be induced by inadequate release of L-arginine-derived nitric oxide impairing ... -
Evaluation of waist-to-height ratio to predict 5 year cardiometabolic risk in sub-Saharan African adults
Ware, L.J.; Kruger, H.S.; Kruger, I.M.; Greeff, M.; Fourie, C.M.T.; Huisman, H.W.; Scheepers, J.D.W.; Uys, A.S.; Kruger, R.; Van Rooyen, J.M.; Schutte, R.; Schutte, A.E. (Open Access, 2014)Background and aims Simple, low-cost central obesity measures may help identify individuals with increased cardiometabolic disease risk, although it is unclear which measures perform best in African adults. We aimed to: ... -
Genetic polymorphisms of beta(2)- and beta(3)- adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women
Van Rooyen, J.M.; Pretorius, P.J.; Britz, M.; Huisman, H.W.; Schutte, A.E.; Towers, G.W.; Olckers, A.; Malan, N.T.; Malan, L.; Schutte, R. (Thieme, 2008)Background: Genetic variation in the β2 (ADRB2) and β3 (ADRB3) adrenergic receptor genes are associated with obesity and insulin resistance. To further elucidate the role of these genes in the pathophysiology of obesity ... -
The link between vascular deterioration and branched chain amino acids in a population with high glycated haemoglobin: the SABPA study
Mels, C.M.; Schutte, A.E.; Schutte, R.; Huisman, H.W.; Smith, W. (Springer Link, 2013)Globally the prevalence of non-communicable diseases, such as hypertension and type 2 diabetes, are escalating. Metabolomic studies indicated that circulating branched chain amino acids (BCAAs) are associated with insulin ... -
NT-proBNP is associated with fibulin-1 in Africans: The SAfrEIC study
Kruger, R.; Schutte, R.; Huisman, H.W.; Schutte, A.E.; Argraves, W.S.; Rasmussen, L.; Olsen, M.D. (Elsevier, 2012)Objectives The N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is involved in the regulation of volume load and secreted when systemic cardiac overload occurs. Fibulin-1 on the other hand is a component of ... -
Plasma renin responses to mental stress and carotid intima-media thickness in black Africans: the SABPA study
Hamer, M.; Malan, L.; Schutte, A.E.; Huisman, H.W.; Van Rooyen, J.M.; Schutte, R.; Foirie, C.M.T.; Malan, N.T. (Nature Publishing Group, 2011)The renin–angiotensin–aldosterone system can be activated by sympathetic nervous input and is thought to have an important role in the prevalence of hypertension and cardiovascular risk in black Africans. We examined (1) ... -
Recent advances in understanding hypertension development in sub-Saharan Africa
Schutte, A.E.; Botha, S.; Fourie, C.M.T.; Gafane-Matemane, L.F.; Kruger, R.; Lammertyn, L.; Malan, L.; Mels, C.M.C.; Schutte, R.; Smith, W.; Van Rooyen, J.M.; Ware, L.J.; Huisman, H.W. (Nature, 2017)Consistent reports indicate that hypertension is a particularly common finding in black populations. Hypertension occurs at younger ages and is often more severe in terms of blood pressure levels and organ damage than in ... -
Should obesity be blamed for the high prevalence rates of hypertension in black South African women?
Schutte, A.E; Huisman, H.W.; Van Rooyen, J.M.; Schutte, R.; Malan, L.; De Ridder, J.H.; Van der Merwe, A.; Malan, N.T. (Nature Publishing Group, 2008)Hypertension is highly prevalent in South Africa, resulting in high stroke mortality rates. Since obesity is very common among South African women, it is likely that obesity contributes to the hypertension prevalence. The ... -
Urinary albumin excretion from spot urine samples predict all-cause and stroke mortality in Africans
Schutte, R.; Schmieder, R.E.; Huisman, H.W.; Smith, W.; Van Rooyen, J.M.; Fourie, C.M.T.; Kruger, R.; Uys, L.; Ware, L.; Mels, C.M.C.; Greeff, M; Kruger, I.M.; Schutte, A.E. (Oxford University Press, 2014)BACKGROUND: Increased urinary albumin excretion reflects general vascular damage and predicts adverse cardiovascular and renal outcomes. Albuminuria can be determined from easily collected spot urine samples, especially ...