Browsing Faculty of Health Sciences by Author "Huisman, Hugo W."
Now showing items 1-20 of 30
-
Are behavioural risk factors to be blamed for the conversion from optimal blood pressure to hypertensive status in black South Africans? A 5-year prospective study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Fourie, Carla M.T. (Oxford University Press, 2012)Background Longitudinal cohort studies in sub-Saharan Africa are urgently needed to understand cardiovascular disease development. We, therefore, explored health behaviours and conventional risk factors of African individuals ... -
Arterial stiffness, ambulatory blood pressure and low-grade albuminuria in non-diabetic African and caucasian men: the SABPA study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Glyn, Matthew C.P.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Fourie, Carla M.T.; Malan, Leoné (Nature Publishing Group, 2011)Recent evidence suggests that low-grade urinary albumin excretion is a marker of early general attenuation of vascular function, but studies are limited to Caucasian population groups. We compared low-grade urinary albumin ... -
The association of 25(OH)D with blood pressure, pulse pressure and carotid–radial pulse wave velocity in African women
Kruger, Iolanthé M.; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Schutte, Rudolph; Malan, Leoné; Malan, Nicolaas T.; Fourie, Carla M.T.; Kruger, Annamarie (Public Library of Science, 2013)High susceptibility of the African population to develop cardiovascular disease obliges us to investigate possible contributing risk factors. Our aim was to determine whether low 25(OH)D status is associated with increased ... -
The Association of Red Blood Cell Counts with Endothelin-1 in African and Caucasian Women
Huisman, Hugo W.; Schutte, Aletta E.; Van Rooyen, Johannes M.; Schutte, Rudolph; Malan, Leoné; Fourie, Catharina M.T.; Malan, Nicolaas T. (Informa Healthcare, 2009)The literature shows an increase in endothelin-1 with increased levels of erythrocytes. There are also indications that inflammation and elevated endothelin-1 levels interact with erythropoiesis. In this study, the association ... -
Associations of cholesterol and glucose with cardiovascular dysfunction in black Africans: the SABPA study
Lammertyn, Leandi; Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Fourie, Carla M.T.; Malan, Leoné (Informa healthcare, 2011)The aim was to determine whether blood glucose or cholesterol is the more prominent contributor to cardiovascular dysfunction in 101 African men and 99 African women. We measured ambulatory daytime blood pressure (BP), ... -
Blood glutathione and subclinical atherosclerosis in African men: the SABPA study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Szabolcs, Péter; Fourie, Carla M.T.; Van der Westhuizen, Francois H.; Louw, Roan; Botha, Cindy A.; Malan, Leoné (Oxford Univ Press, 2009)Background: Sub-Saharan Africans face an increasing burden of hypertension and related cardiac and cerebrovascular morbidity and mortality, making the identification of factors leading to early vascular abnormalities ... -
Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: the SABPA study
Schutte, Aletta E.; Schutte, Rudolph; Huisman, Hugo W.; Van Rooyen, Johannes M.; Fourie, Catharina M.T.; Malan, Nicolaas T.; Malan, Leoné (Nature Publishing Group, 2011)The prognostic significance of blood pressure (BP) variability has lately enjoyed considerable attention. The need for early markers of cardiovascular dysfunction is imperative in black South Africans who have a significant ... -
Comparison of central pressure estimates obtained from SphygmoCor, Omron HEM-9000AI and carotid applanation tonometry
Kips, Jan G.; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Fourie, Catharina M.; Malan, Leoné; Schutte, Rudolph (Lipppincott, Williams & Wilkins, 2011)Background: The Omron HEM-9000AI is the first automated tonometer to provide an estimate of central SBP (cSBP), which is considered to be more predictive of cardiovascular events than brachial pressure. However, considerable ... -
Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians
Schutte, Aletta E.; Schutte, Rudolph; Huisman, Hugo W.; Van Rooyen, Johannes M.; Fourie, Carla M.T.; Malan, Leoné; Malan, Nico T.; Schwedhelm, Edzard; Strimbeanu, Sebastian; Anderssohn, Maike; Böger, Rainer H. (BioScintifica, 2010)Objective Alarming increases in hypertension and type 2 diabetes among Africans accentuate the need to identify factors that could serve as targets for prevention or treatment. In Caucasian populations, asymmetric ... -
Drink types unmask the health risks associated with alcohol intake: prospective evidence from the general population
Schutte, Rudolph; Huisman, Hugo W.; Ricci, Cristian; Schutte, Aletta E.; Papageorgiou, Maria (Elsevier, 2020)Background & aims Uncertainty still exists on the impact of low to moderate consumption of different drink types on population health. We therefore investigated the associations of different drink types in the form of ... -
Ethnic and gender differences regarding the insulin-blood pressure relationship
Schutte, Aletta E; Huisman, Hugo W; Palmer, Iolanthe Marike; Schutte, Aletta E; Huisman, Hugo W.; Palmer, Iolanthe Marike (Elsevier, 2009)Ageing is associated with increased insulin and C-peptide levels. Due to a lack of data, our first aim was to establish whether this also holds true for Africans from South Africa. Our second aim was to determine whether ... -
Ethnic-specific correlations of Visfatin with circulating markers of endothelial inflammation and function
Reimann, Manja; Huisman, Hugo W.; Schutte, Rudolph; Malan, Leoné; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Schutte, Aletta E. (Wiley, 2009)Sub-Saharan Africa is afflicted by high hypertension prevalence that is expected to rise even further along with increasing obesity rates. The present study aimed to investigate the role of visfatin in obesity and to explore ... -
Exploring the link between cardiovascular reactivity and end–organ damage in African and Caucasian men: the SABPA study
Huisman, Hugo W.; Schutte, Aletta E.; Schutte, Rudolph; Van Rooyen, Johannes M.; Fourie, Carla M. T. (Oxford University Press, 2013)BACKGROUND Heart failure in the African population is reaching alarming levels. Increased afterload as a result of increased vasoconstriction during stress may lead to impaired ventricular function and stroke volume (SV) ... -
Extracellular matrix biomarker, Fibulin–1 and Its association with Soluble uPAR in a Bi-ethnic South African population: the SAfrEIC study
Du Plooy, Christine S.; Kruger, Ruan; Huisman, Hugo W.; Rasmussen, Lars M.; Eugen-Olsen, Jesper; Schutte, Aletta E. (Elsevier, 2015)Background Fibulin-1 and soluble urokinase-type plasminogen activator receptor (suPAR) emerged as mediators in the development of sclerotic disease. SuPAR along with C-reactive protein (CRP) and albumin delineate ... -
Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study
Malan, Leoné; Harvey, Brian H.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Schutte, Rudolph; Schutte, Aletta E.; Fourie, Carla M.T.; Malan, Nico T. (Kluwer, 2012)Background: Defensive active coping responses (being-in-control, acceptance of the stressor as reality) have been associated with vascular hyper-responsiveness in urban Africans. However, the association between active ... -
Hyperuricaemia is an independent factor for the metabolic syndrome in a sub-Saharan African population: a factor analysis
Reimann, Manja; Schutte, Aletta E.; Malan, Leoné; Huisman, Hugo W.; Malan, Nicolaas T. (Elsevier, 2008)Objective To assess the risk factor pattern of the metabolic syndrome and its association with insulin resistance and hyperuricaemia in a sub-Saharan African population with different levels of urbanisation. Methods Four ... -
The influence of cardiac and vascular responses on basesline cardiovascular parameters in black african children
Fourie, Carla M.T.; Van Rooyen, Johannes M.; Huisman, Hugo W.; Malan, Nicolaas T.; Schutte, Rudolph; Malan, Leoné; Schutte, Aletta E. (Allen Press Online Publishing, 2008)Background: The prevalence of hypertension among Black adults in South Africa is high. Because cardiovascular reactivity can be used to predict hypertension in later life, we attempted to determine whether cardiac ... -
L-Carnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: the SABPA study
Mels, Catharina M. C.; Schutte, Aletta E.; Erasmus, Elardus; Huisman, Hugo W.; Schutte, Rudolph; Fourie, Carla M.T.; Kruger, Ruan; Van Rooyen, Johannes M.; Smith, Wayne; Malan, Nicolaas T.; Malan, Leoné (Springer, 2013)The prevalence of hypertension in sub-Saharan Africa is increasing rapidly, and treatment remains challenging. Although the use of l-carnitine in treatment has received much attention, studies reporting on physiological ... -
Low testosterone and hyperkinetic blood pressure responses in a cohort of South African men: the SABPA study
Malan, Nicolaas T.; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Schutte, Rudolph; Mels, Catharina M.; Steyn, Hendrik S.; Smith, Wayne; Fourie, Carla M.; Glyn, Matthew; Malan, Leoné (Taylor & Francis, 2013)Hypertension (HT) and the metabolic syndrome are major problems in Africa. The role of sex hormones in the cardiovascular profile of black Africans in South Africa has not been studied. Our objective was to study the ... -
NT–proBNP, C–reactive protein and soluble uPAR in a Bi–ethnic male population: the SAfrEIC study
Kruger, Ruan; Schutte, Rudolph; Huisman, Hugo W.; Olsen, Michael H.; Schutte, Aletta E. (Public Library of Science, 2013)Objective and design: This cross-sectional study aimed to investigate associations between a marker of cardiac strain, the N-terminal prohormone B-type natriuretic peptide (NT-proBNP), and inflammation as reflected by ...