Now showing items 1-2 of 2

    • Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy 

      Aminake, Makoah N.; Grobler, Anne; Kumar, Vipan; Hans, Renate; Wiesner, Lubbe; Aminake, Makoah N.; Grobler, Anne; Kumar, Vipan; Hans, Renate; Wiesner, Lubbe (Elsevier, 2012)
      Malaria and HIV are among the most important global health problems of our time and together are responsible for approximately 3 million deaths annually. These two diseases overlap in many regions of the world including ...
    • Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids 

      Pretorius, Stefan I.; Breytenbach, Wilma J.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2013)
      The aim of this study was to synthesize a series of quinoline–pyrimidine hybrids and to evaluate their in vitro antimalarial activity as well as cytotoxicity. The hybrids were brought about in a two-step nucleophilic s ...