Now showing items 1-5 of 5

    • The case for development of 11-aza-artemisinins for malaria 

      Harmse, Rozanne; Smit, Frans; Haynes, Richard K.; N'Da, David D.; Wong, Ho Ning (Bentham Science, 2015)
      The current treatment regimens for uncomplicated malaria comprise an artemisinin in combination with another drug (ACT). However, the recent emergence of resistance to ACTs in South East Asia dramatically emphasizes the ...
    • Evaluation of isolated fractions of aloe vera gel materials on indinavir pharmacokinetics: in vitro and in vivo studies 

      Wallis, Lonette; Malan, Maides; Gouws, Chrisna; Steyn, Dewald; Ellis, Suria; Hamman, Josias; Otto, Daniel P. (Bentham Science, 2016)
      Aloe vera is a plant with a long history of traditional medicinal use and is consumed in different products, sometimes in conjunction with prescribed medicines. A. vera gel has shown the ability to modulate drug absorption ...
    • Herb-drug pharmacokinetic interactions: transport and metabolism of indinavir in the presence of selected herbal products 

      Calitz, Carlemi; Gouws, Chrisna; Viljoen, Joe; Steenekamp, Jan; Hamman, Josias (MDPI, 2015)
      Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions ...
    • Impact of traditional African medicine on drug metabolism and transport 

      Calitz, Carlemi; Steenekamp, Jan H.; Steyn, Johan D.; Gouws, Chrisna; Viljoen, Joe M.; Hamman, Josias H. (Taylor & Francis, 2014)
      Introduction: Africa is a continent of rich plant biodiversity with many indigenous plants having a long history of being used for medicinal purposes. A considerable number of patients consult traditional healers in ...
    • Isolation-induced behavioural changes in a genetic animal model of depression 

      Fischer, Christina W.; Wegener, Gregers; Liebenberg, Nico; Elfving, Betina; Lund, Sten; Fischer, Christina W.; Wegener, Gregers; Liebenberg, Nico; Elfving, Betina; Lund, Sten (Elsevier, 2012)
      Depression is a heterogeneous disorder displaying a range of symptoms including feelings of despair and social withdrawal. Social isolation may complicate the progression of depression and have effects on both behaviour ...