Now showing items 1-6 of 6

    • Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration 

      Hayeshi, Rose; Kalombo, Lonji; Ramalapa, Bathabile; Semete, Boitumelo; Booysen, Laetitia; Swai, Hulda S.; Hayeshi, Rose; Kalombo, Lonji; Ramalapa, Bathabile; Semete, Boitumelo; Booysen, Laetitia; Swai, Hulda S. (Elsevier, 2012)
      The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study ...
    • In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems 

      Semete, Boitumelo; Booysen, Laetitia; Lemmer, Yolandy; Kalombo, Lonji; Katata, Lebogang; Verschoor, Jan; Swai, Hulda S.; Semete, Boitumelo; Booysen, Laetitia; Lemmer, Yolandy; Kalombo, Lonji; Katata, Lebogang; Verschoor, Jan; Swai, Hulda S. (Elsevier, 2010)
      The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects of these particles have raised some ...
    • Particle size and metal composition of gouging and lancing fumes 

      Keyter, Marelé; Van der Merwe, Alicia; Franken, Anja (Taylor & Francis, 2019)
      Metal gouging and lancing liberate particles of an unknown size and composition. Fumes are formed when vaporized materials condense in air, creating fine and ultrafine particles which can agglomerate. Particle sizes may ...
    • Permeation of PLGA nanoparticles across different in vitro models 

      Nkabinde, Lindiwe A.; Hamman, Josias H.; Shoba-Zikhali, Lungile N.N.; Semete-Makokotlela, Boitumelo; Kalombo, Lonji; Nkabinde, Lindiwe A.; Hamman, Josias H.; Shoba-Zikhali, Lungile N.N.; Semete-Makokotlela, Boitumelo; Kalombo, Lonji (Bentham Science, 2012)
      Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance ...
    • Pulmonary delivery of antitubercular drugs using spray-dried lipid-polymer hybrid nanoparticles 

      Bhardwaj, Ankur; Grobler, Anne; Mehta, Abhinav; Mehta, Shuchi; Yadav, Shailendra (Taylor & Francis, 2016)
      The present study aimed to develop lipid–polymer hybrid nanoparticles (LPNs) for the combined pulmonary delivery of isoniazid (INH) and ciprofloxacin hydrochloride (CIP HCl). Drug-loaded LPNs were prepared by the ...
    • Samarium oxide as a radiotracer to evaluate the in vivo biodistribution of PLGA nanoparticles 

      Mandiwana, Vusani; Grobler, Anne; Zeevaart, Jan Rijn; Kalombo, Lonji; Venter, Kobus (Springer, 2015)
      Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim of ...