Now showing items 1-3 of 3

    • Deuterium isotope effects for the oxidation of 1-methyl-3phenyl-3pyrrolinyl analogues by monoamine oxidase B 

      Pretorius, Anél; Ogunrombi, Modupe O.; Terre'Blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P.; Pretorius, Anél; Ogunrombi, Modupe O.; Terre'Blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2008)
      The parkinsonian inducing agent, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is a cyclic tertiary allylamine exhibiting good monoamine oxidase B (MAO-B) substrate properties. MAO-B catalyzes the ring α-carbon ...
    • Interactions of 1-methyl-3-phenylpyrrolidine and 3-methyl-1-phenyl-3-azabicyclo[3.1.0]hexane with monoamine oxidase B 

      Pretorius, Anél; Ogunrombi, Modupe O.; Fourie, Hendrik; Terre'blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P.; Pretorius, Anél; Ogunrombi, Modupe O.; Fourie, Hendrik; Terre'blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2010)
      The parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its corresponding five-membered ring analogue 1-methyl-3-phenyl-3-pyrroline are cyclic tertiary allylamines and good substrates of ...
    • Structure-activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles 

      Ogunrombi, Modupe O.; Malan, Sarel F.; Terre'Blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P.; Ogunrombi, Modupe O.; Malan, Sarel F.; Terre'Blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2008)
      1-Methyl-3-phenyl-3-pyrrolines are structural analogues of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and like MPTP are selective substrates of monoamine oxidase B (MAO-B). As part of an ongoing ...