Browsing Faculty of Health Sciences by Subject "Pharmacokinetics"
Now showing items 1-6 of 6
-
Antimalarial and anticancer activities of artemisinin-quinoline hybrid-dimers and pharmacokinetic properties in mice
(Elsevier, 2012)Malaria, one of the three most important life-threatening infectious diseases, is recommended to be treated with ACT (artemisinin combination therapy) against which Plasmodium falciparum already displayed resistance. Two ... -
Combination therapy of western drugs and herbal medicines: recent advances in understanding interactions involving metabolism and efflux
(Taylor & Francis, 2012)Introduction: While complementary and alternative medicine markets prosper with an increasing number of consumers of herbal medicines, there is an associated likelihood for herb–drug interactions to occur. Modulation of ... -
The effect of the Pheroid delivery system on the in vitro metabolism and in vivo pharmacokinetics of artemisone
(Taylor & Francis, 2014)Objectives: The objectives were to determine the pharmacokinetics (PK) of artemisone and artemisone formulated in the Pheroid® drug delivery system in primates and to establish whether the formulation affects the in vitro ... -
Impact of traditional African medicine on drug metabolism and transport
(Taylor & Francis, 2014)Introduction: Africa is a continent of rich plant biodiversity with many indigenous plants having a long history of being used for medicinal purposes. A considerable number of patients consult traditional healers in ... -
In vitro efficacies, ADME, and pharmacokinetic properties of phenoxazine derivatives active against Mycobacterium tuberculosis
(ASM, 2019)Mycobacterium tuberculosis, the causative agent of tuberculosis, remains a leading infectious killer globally, demanding the urgent development of faster-acting drugs with novel mechanisms of action. Riminophenazines such ... -
In vitro oral drug permeation models: the importance of taking physiological and physico-chemical factors into consideration
(Taylor & Francis, 2016)Introduction: The assessment of intestinal membrane permeability properties of new chemical entities is a crucial step in the drug discovery and development process and a variety of in vitro models, methods and techniques ...