Now showing items 1-6 of 6

    • Essential fatty acids as transdermal penetration enhancers 

      Van Zyl, Lindi; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta; Viljoen, Joe (Elsevier, 2016)
      The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ...
    • Exploratory data analysis of the dependencies between skin permeability, molecular weight and log P 

      Kilian, D.; Lemmer, H.J.R.; Gerber, M.; Du Preez, J.L.; Du Plessis, J. (Govi-Verlag, 2016)
      Molecular weight and log P remain the most frequently used physicochemical properties in models that predict skin permeability. However, several reports over the past two decades have suggested that predictions made by ...
    • Synthesis and transdermal penetration of stavudine-5'-esters. 

      Holmes, Estee-Marie; Breytenbach, Jaco C.; Gerber, Minja; Du Plessis, Jeanetta; Holmes, Estee-Marie; Breytenbach, Jaco C.; Gerber, Minja; Du Plessis, Jeanetta (Bentham Science, 2010)
      The aim of this study was to investigate the effects of different ester groups in position 5’ of stavudine on the transdermal penetration with and without the use of Pheroid™ as the delivery system. Six esters were prepared ...
    • Topical and transdermal delivery of L-carnitine 

      Fox, L.T.; Gerber, M.; Grobler, A.; Du Preez, J.L.; Du Plessis, J.; Fox, L.T.; Gerber, M.; Grobler, A.; Du Preez, J.L.; Du Plessis, J. (Karger, 2011)
      Background: The two types of skin aging (intrinsic and extrinsic) share important molecular features, while having distinct differences on the macromolecular level: both lead to increased production of reactive oxygen ...
    • Topical delivery of acyclovir and ketoconazole 

      Jacobs, Gerda A.; Gerber, Minja; Malan, Maides M.; Du Preez, Jan L.; Fox, Lizelle T.; Du Plessis, Jeanetta (Taylor & Francis, 2014)
      Context: Viral and fungal cutaneous manifestations are regularly encountered in immunocompromised HIV/AIDS individuals and can be treated by drugs such as acyclovir and ketoconazole, respectively. Objective: The aim of ...
    • Vesicular carriers for skin drug delivery: the Pheroid™ technology 

      Kilian, Dewald; Shahzad, Yasser; Fox, Lizelle; Gerber, Minja; Du Plessis, Jeanetta (Bentham Science, 2015)
      The skin remains an attractive area for drug delivery. The skin, however, often limits the ingress of drugs, because of its very low permeability. Much research, focusing on employing a variety of physical and chemical ...