Now showing items 1-10 of 15

    • 2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase 

      Nel, Magdalena S.; Petzer, Anél; Petzer, Jacobus P.; Legoabe, Lesetja J. (Elsevier, 2016)
      In the present study, a series of twenty-two 2-benzylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 2-benzylidene-1-indanone derivatives ...
    • 3-Coumaranone derivatives as inhibitors of monoamine oxidase 

      Van Dyk, Adriaan S.; Petzer, Jacobus P.; Petzer, Anél; Legoabe, Lesetja J. (Dove Press, 2015)
      The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone ...
    • Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase 

      Petzer, Anél; Harvey, Brian H.; Petzer, Jacobus P.; Wegener, Gregers; Petzer, Anél; Harvey, Brian H.; Petzer, Jacobus P.; Wegener, Gregers (Elsevier, 2012)
      Methylene blue (MB) has been shown to act at multiple cellular and molecular targets and as a result possesses diverse medical applications. Among these is a high potency reversible inhibition of monoamine oxidase A ...
    • Evaluation of natural and synthetic 1,4-naphthoquinones as inhibitors of monoamine oxidase 

      Mostert, Samantha; Petzer, Anél; Petzer, Jacobus P. (Wiley, 2016)
      Previous reports have documented that 1,4-naphtho- quinones act as inhibitors of the monoamine oxidase (MAO) enzymes. In particular, fractionation of the extracts of cured tobacco leafs has led to the charac- terization ...
    • Inhibition of monoamine oxidase by benzoxathiolone analogues 

      Mostert, Samantha; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2016)
      Inhibitors of the monoamine oxidase (MAO) enzymes are considered useful therapeutic agents, and are used in the clinic for the treatment of depressive illness and Parkinson’s disease. In addition, MAO inhibitors are also ...
    • The inhibition of monoamine oxidase by esomeprazole 

      Petzer, A.; Pienaar, A.; Petzer, J.P. (Thieme, 2013)
      Virtual screening of a library of drugs has suggested that esomeprazole, the S-enantiomer of omeprazole, may possess binding affinities for the active sites of the monoamine oxidase (MAO) A and B enzymes. Based on this ...
    • Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives 

      Chirkova, Zhanna V.; Petzer, Anél; Petzer, Jacobus P.; Kabanova, Mariya V.; Filimonov, Sergey I. (Elsevier, 2015)
      Recent studies have found that phthalonitrile derivatives are remarkably potent inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to further determine the structure-activity relationships (SARs) for MAO ...
    • The interactions of azure B, a metabolite of methylene blue, with 2 acetylcholinesterase and butyrylcholinesterase 

      Petzer, Anél; Harvey, Brian H.; Petzer, Jacobus P. (Elsevier, 2014)
      Methylene blue(MB) is reported to possess diverse pharmacological actions and is attracting increasing attention for the treatment of neurodegenerative disorders such as Alzheimer's disease. Among the pharmacological actions ...
    • The interactions of caffeine with monoamine oxidase 

      Petzer, Anél; Pienaar, Anke; Petzer, Jacobus P. (Elsevier, 2013)
      Aims: Caffeine has been used as a scaffold for the design of inhibitors of monoamine oxidase (MAO) A and B. Substitution at the C8 position with a variety of moieties yields structures with high MAO inhibition ...
    • Leflunomide, a reversible monoamine oxidase inhibitor 

      Petzer, Jacobus P.; Petzer, Anél (Bentham Science, 2016)
      A screening study aimed at identifying inhibitors of the enzyme, monoamine oxidase (MAO), among clinically used drugs have indicated that the antirheumatic drug, leflunomide, is an inhibitor of both MAO isoforms. Leflunomide ...