Now showing items 1-3 of 3

    • Synthesis and transdermal penetration of stavudine-5'-esters. 

      Holmes, Estee-Marie; Breytenbach, Jaco C.; Gerber, Minja; Du Plessis, Jeanetta; Holmes, Estee-Marie; Breytenbach, Jaco C.; Gerber, Minja; Du Plessis, Jeanetta (Bentham Science, 2010)
      The aim of this study was to investigate the effects of different ester groups in position 5’ of stavudine on the transdermal penetration with and without the use of Pheroid™ as the delivery system. Six esters were prepared ...
    • Synthesis and transdermal permeation of novel N4-methoxypoly(ethylene glycol) carbamates of cytarabine 

      Legoabe, Lesetja J.; N'Da, David D.; Breytenbach, Jaco C.; Du Preez, Jan L.; Du Plessis, Jeanetta; Legoabe, Lesetja J.; N'Da, David D.; Breytenbach, Jaco C.; Du Preez, Jan L.; Du Plessis, Jeanetta (Taylor & Francis, 2010)
      Background: Cytarabine is a deoxycytidine analogue commonly used in the treatment of hematological malignant diseases. Its clinical utility, however, is severely limited by its short plasma half-life because of the catabolic ...
    • Transdermal penetration of zalcitabine, lamivudine and synthesised N-acyl lamivudine ester 

      Gerber, Minja; Breytenbach, Jaco C.; Du Plessis, Jeanetta; Gerber, Minja; Breytenbach, Jaco C.; Du Plessis, Jeanetta (Elsevier, 2008)
      The objective of this study was to determine the in vitro transdermal permeation through human epidermis of zalcitabine, lamivudine and the synthesised N-acyl lamivudine esters, with and without the use of Pheroid™ as ...