Now showing items 1-6 of 6

    • Effect of penetration modifiers on the dermal and transdermal delivery of drugs and cosmetic active ingredients 

      Otto, A.; Hadgraft, J.; Du Plessis, J.; Wiechers, J.W.; Kelly, C.L.; Otto, A.; Hadgraft, J.; Du Plessis, J.; Wiechers, J.W.; Kelly, C.L. (Karger, 2008)
      In this study the effect of 2 penetration modifiers, dimethyl isosorbide (DMI) and diethylene glycol monoethyl ether (DGME) on the skin delivery of hydroquinone (HQ), salicylic acid (SA) and octadecenedioic acid (DIOIC) ...
    • The effects of emulsifiers and emulsion formulation types on dermal and transdermal drug delivery 

      Otto, Anja; Du Plessis, Jeanetta (Springer, 2015)
      Emulsions are widely used in the cosmetic and pharmaceutical fields for the topical administration of hydrophilic and lipophilic active ingredients. There exist different types of emulsions, e.g. water-in-oil, oil-in-water, ...
    • Optimised transdermal delivery of pravastatin 

      Burger, Cornel; Gerber, Minja; Du Preez, Jan L.; Du Plessis, Jeanetta (Elsevier, 2015)
      Wiechers’ programme “Formulating for Efficacy” initiated a new strategy to optimise the oil phase of topical formulations in order to achieve optimal transdermal drug delivery. This new approach uses the “Delivery Gap ...
    • Stability, clinical efficacy and antioxidant properties of honeybush extracts in semi-solid formulations. 

      Gerber, Gezina S.F.W.; Fox, Lizelle T.; Gerber, Minja; Du Preez, Jan L.; Van Zyl, Sterna; Boneschans, Banie; Du Plessis, Jeanetta (Medknow Publications, 2015)
      Background: Honeybush extracts (Cyclopia spp.) can be incorporated into skin care products to treat conditions such as skin dryness and can function as an anti-oxidant. Objective: To formulate Honeybush formulations and ...
    • Synthesis and transdermal penetration of stavudine-5'-esters. 

      Holmes, Estee-Marie; Breytenbach, Jaco C.; Gerber, Minja; Du Plessis, Jeanetta; Holmes, Estee-Marie; Breytenbach, Jaco C.; Gerber, Minja; Du Plessis, Jeanetta (Bentham Science, 2010)
      The aim of this study was to investigate the effects of different ester groups in position 5’ of stavudine on the transdermal penetration with and without the use of Pheroid™ as the delivery system. Six esters were prepared ...
    • Transdermal penetration of zalcitabine, lamivudine and synthesised N-acyl lamivudine ester 

      Gerber, Minja; Breytenbach, Jaco C.; Du Plessis, Jeanetta; Gerber, Minja; Breytenbach, Jaco C.; Du Plessis, Jeanetta (Elsevier, 2008)
      The objective of this study was to determine the in vitro transdermal permeation through human epidermis of zalcitabine, lamivudine and the synthesised N-acyl lamivudine esters, with and without the use of Pheroid™ as ...