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Prospective analysis of the medicine possession ratio of antidepressants in the private health sector of South Africa, 2006-2011
(Health & Medical Publishing Group, 2015)
Background: Major depressive disorder (MDD) is a disabling mental illness with high morbidity and mortality rates. Inadequate treatment
efficacy, unfavourable side-effect profiles and consequent shortfalls in compliance ...
Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response
(Springer, 2015)
Rationale Major depression has been associated with higher
levels of air pollution that in turn leads to neurodegeneration
via increased oxidative stress. There is a need for suitable
translational animal models to study ...
The impact of HIV/AIDS on compliance with antidepressant treatment in major depressive disorder: a prospective study in a South African private healthcare cohort
(BioMed Central, 2015)
Background: MDD and HIV/AIDS have a high prevalence worldwide with severe consequences for patients. In
both conditions, compliance with treatment is key to successfully treat these disorders. In the current study, ...
Neurodevelopmental animal models reveal the convergent role of neurotransmitter systems, inflammation, and oxidative stress as biomarkers of schizophrenia: implications for novel drug development
(ACS, 2015)
Schizophrenia is a life altering disease with a complex
etiology and pathophysiology, and although antipsychotics are
valuable in treating the disorder, certain symptoms and/or sufferers
remain resistant to treatment. ...
Of mice and marbles: novel perspectives on burying behavior as a screening test for psychiatric illness
(Springer, 2016)
Burying forms part of the normal behavioral routine of rodents, although its expression is species-specific. However, it has been suggested that aberrant burying behavior, of which marble-burying (MB) is an example, may ...
A review of biomarkers in mood and psychotic disorders: a dissection of clinical vs. preclinical correlates
(Bentham Science, 2015)
Despite significant research efforts aimed at understanding the neurobiological underpinnings of mood (depression, bipolar disorder) and psychotic disorders, the diagnosis and evaluation of treatment of these disorders are ...
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates
(Associação Brasileira de Psiquiatria (ABP), 2016)
Objective: In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important.
Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist
on genetic associations. ...
Late-life effects of chronic methamphetamine exposure during puberty on behaviour and corticostriatal mono-amines in social isolation-reared rats
(Karger, 2014)
Chronic methamphetamine (MA) abuse results in an acute psychosis indistinguishable from paranoid schizophrenia. However, less is known of the interaction between MA use and environmental insults, and how this contributes ...
Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
(Elsevier, 2013)
Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory
abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine
release . N-acetyl cysteine ...
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
(Springer, 2013)
Schizophrenia is causally associated with early-life
environmental stress, implicating oxidative stress in its pathophysiology.
N-acetyl cysteine (NAC), a glutathione precursor
and antioxidant, is emerging as a useful ...