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Modeling nanoparticle delivery of TB drugs to granulomas
(Elsevier, 2016)
Tuberculosis, which typically presents as a pulmonary disease, has a complex pathology. The primary site of infection, the Ghon focus, recruits immune cells and a granuloma forms. At earlier stages the granuloma is still ...
2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2016)
In the present study a series of fifteen 2-heteroarylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. These compounds are structurally related ...
Decreased in vivo α2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression
(Elsevier, 2015)
Depression is a debilitating heterogenous disorder and the underlying mechanisms remain elusive. Alterations in monoaminergic neurotransmission, including noradrenergic, have been implicated in the etiology of depression. ...
Comparing antibody responses in chickens against Plasmodium falciparum lactate dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase with Freund’s and Pheroid® adjuvants
(Taylor & Francis, 2015)
Pheroid® technology was assessed as an alternative to Freund’s adjuvant to raise antibodies in experimental animals. Chickens were immunized with two recombinantly expressed Plasmodium falciparum proteins, lactate dehydrogenase ...
The adenosine receptor affinities and monoamine oxidase B inhibitory properties of sulfanylphthalimide analogues
(Elsevier, 2015)
Based on a report that sulfanylphthalimides are highly potent monoamine oxidase (MAO) B selective inhibitors, the present study examines the adenosine receptor affinities and MAO-B inhibitory properties of a series of 4- ...
Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression
(Cambridge Univ Press, 2015)
Objective: We investigated whether the nitric oxide (NO) precursor,
L-arginine, can prevent the antidepressant-like action of the fast-acting
antidepressant, ketamine, in a genetic rat model of depression, and/or
induce ...
Carbon-14 radiolabeling and in vivo biodistribution of a potential anti-TB compound
(Wiley, 2015)
A potential anti-TB compound bearing a nitroimidazole moiety from iThemba Pharmaceuticals TB chemical library exhibits
promising in vitro activity in the microplate almar blue assay (MABA) with a minimum inhibitory ...
Indanones as high-potency reversible inhibitors of monoamine oxidase
(Wiley, 2015)
Recent reports document that α-tetralone (3,4-dihydro-2H-naphthalen-1-one) is an appropriate scaffold for the design of high-potency monoamine oxidase (MAO) inhibitors. Based on the structural similarity between α-tetralone ...
Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response
(Springer, 2015)
Rationale Major depression has been associated with higher
levels of air pollution that in turn leads to neurodegeneration
via increased oxidative stress. There is a need for suitable
translational animal models to study ...
Monoamine oxidase inhibitory activities of heterocyclic chalcones
(Elsevier, 2015)
Studies have shown that natural and synthetic chalcones (1,3-diphenyl-2-propen-1-ones) possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the present study is a report that a series of ...