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Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity
(Society for Neuroscience, 2015)
Neuropeptide S (NPS) has generated substantial interest due to its anxiolytic and fear-attenuating effects in rodents, while a corresponding
receptor polymorphism associated with increased NPS receptor (NPSR1) surface ...
Synthesis, 68Ga-radiolabeling, and preliminary in vivo assessment of a depsipeptide-derived compound as a potential PET/CT infection imaging agent
(Hindawi, 2015)
Noninvasive imaging is a powerful tool for early diagnosis and monitoring of various disease processes, such as infections. An
alarming shortage of infection-selective radiopharmaceuticals exists for overcoming the ...
Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene
(Oxford Univ Press, 2015)
Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has ...
Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium
(Oxford Univ Press, 2015)
Background: Telomeres are protective DNA-protein complexes at the ends of each chromosome, maintained primarily by the enzyme telomerase. Shortening of the blood leukocyte telomeres is associated with aging, several chronic ...
Prospective analysis of the medicine possession ratio of antidepressants in the private health sector of South Africa, 2006-2011
(Health & Medical Publishing Group, 2015)
Background: Major depressive disorder (MDD) is a disabling mental illness with high morbidity and mortality rates. Inadequate treatment
efficacy, unfavourable side-effect profiles and consequent shortfalls in compliance ...
The impact of HIV/AIDS on compliance with antidepressant treatment in major depressive disorder: a prospective study in a South African private healthcare cohort
(BioMed Central, 2015)
Background: MDD and HIV/AIDS have a high prevalence worldwide with severe consequences for patients. In
both conditions, compliance with treatment is key to successfully treat these disorders. In the current study, ...
Dual radiolabeling as a technique to track nanocarriers: the case of gold nanoparticles
(MDPI, 2015)
Gold nanoparticles (AuNPs) have shown great potential for use in nanomedicine and nanotechnologies due to their ease of synthesis and functionalization. However, their apparent biocompatibility and biodistribution is still ...
3-Coumaranone derivatives as inhibitors of monoamine oxidase
(Dove Press, 2015)
The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone ...
Public knowledge, attitudes and behaviour towards antibiotic usage in Windhoek, Namibia
(Taylor & Francis, 2015)
Background: The development of antibiotic resistance is a globally recognised human health threat. Overuse of antibiotics is
a major contributory factor to the development of resistance. As end users, the public play a ...
2-Acetylphenol analogs as potent reversible monoamine oxidase inhibitors
(Dove Press, 2015)
Based on a previous report that substituted 2-acetylphenols may be promising leads for the design of novel monoamine oxidase (MAO) inhibitors, a series of C5-substituted 2-acetylphenol analogs (15) and related compounds ...