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Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
(Elsevier, 2013)
Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory
abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine
release . N-acetyl cysteine ...
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
(Springer, 2013)
Schizophrenia is causally associated with early-life
environmental stress, implicating oxidative stress in its pathophysiology.
N-acetyl cysteine (NAC), a glutathione precursor
and antioxidant, is emerging as a useful ...
Neuroprogression in schizophrenia: pathways underpinning clinical staging and therapeutic corollaries
(Sage, 2014)
Objective: Whilst dopaminergic dysfunction remains a necessary component involved in the pathogenesis of schizophrenia,
our current pharmacological armoury of dopamine antagonists does little to control the negative ...
Studies on haloperidol and adjunctive alpha-mangostin or raw Garcinia Mangostana Linn pericarp on bio-behavioral markers in an immune-inflammatory model of schizophrenia in male rats
(Frontiers Media, 2020)
The nematicidal activity of crudely milled powders of stems, leaves, and bulbs of Cassia abbreviata, Cissus cactiformis, Euphorbia ingens, Ipomoea kituiensis, Synadenium cupulare, Senna petersiana, Urigenia sanguinea, ...
Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial
(ABP - Brazilian Psychiatric Association, 2019)
Objective: Bipolar depression is characterized by neurobiological features including perturbed oxidative
biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers.
Bipolar depression ...
Ketamine and rapidly acting antidepressants: breaking the speed of sound or light?
(Sage, 2018)
There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key ...