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The therapeutic potential of Mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia
(Frontiers Media, 2019)
New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic ...
Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: role of corticosterone, oxytocin, and vasopressin
(Sage, 2019)
Background:
The chronobiotic antidepressant, agomelatine, acts via re-entrainment of circadian rhythms. Earlier work has demonstrated late-life anxiety and reduced corticosterone in post-weaning social isolation reared ...
Animal models of major depressive disorder and the implications for drug discovery and development
(Taylor & Francis, 2019)
Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is ...
Translational medicine strategies in PTSD drug development
(Elsevier, 2019)
Once considered a normal response to an abnormal traumatic event, posttraumatic stress disorder (PTSD) has been reconceptualized in terms of unusual persistence of fear-conditioned responses. Selective serotonin reuptake ...
Esketamine and rapastinel, but not imipramine, have antidepressant-like effect in a treatment-resistant animal model of depression
(Cambridge Univ Press, 2019)
Objectives:
Treatment-resistance to antidepressants is a major problem in the pharmacotherapy of major depressive disorder (MDD). Unfortunately, only a few animal models are suitable for studying treatment-resistant ...
Pathological consequences of drug abuse: implication of redox imbalance. Editorial
(Hindawi, 2019)
The onset, progression, and outcome of numerous pathological conditions, affecting different organs and systems, have
been widely reported to be significantly impacted by the
abuse of psychoactive compounds. In the last ...
Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial
(ABP - Brazilian Psychiatric Association, 2019)
Objective: Bipolar depression is characterized by neurobiological features including perturbed oxidative
biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers.
Bipolar depression ...
A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forward
(Springer, 2019)
Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety- and compulsive-like behaviors or anxiolytic and anticompulsive drug action. However, the test responds ...
Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
(Elsevier, 2019)
Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence ...