Search
Now showing items 1-6 of 6
S-ketamine rapidly reverses synaptic and vascular deficits of hippocampus in genetic animal model of depression
(Oxford Univ Press, 2017)
Background:
The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce a rapid antidepressant effect within hours. In ...
Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment
(Wiley, 2013)
Depressive disorders and the treatment thereof have been associated
with a number of neuroplastic events, such as neurogenesis and synaptic remodeling
in discrete areas of the brain. The associations of these events in ...
The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine
(Elsevier, 2020)
We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated ...
Quantitative hippocampal structural changes following elctroconvulsive seizure treatment in a rat model of depression
(Wiley, 2012)
Objective: The pathophysiology of depression and the effects of antidepressant
treatment are hypothesized to be related to hippocampal structural
changes. This study aims to investigate the effect of electroconvulsive ...
Neurovascular plasticity of the hippocampus one week after a single dose of ketamine in genetic rat model of depression
(Wiley, 2016)
Glutamatergic system and the structural plasticity hypothesis are principal components for rapid and sustained antidepressant effects of novel antidepressant therapeutics. This study represents the first investigation of ...
Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus
(Wiley, 2017)
Background and purpose
Astroglia contribute to the pathophysiology of major depression and antidepressant drugs act by modulating synaptic plasticity; therefore, the present study investigated whether the fast antidepressant ...