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Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression
(Springer, 2016)
Rationale
The mechanisms mediating ketamine’s antidepressant effect have only been partly resolved. Recent preclinical reports implicate serotonin (5-hydroxytryptamine; 5-HT) in the antidepressant-like action of ketamine. ...
A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats
(Cambridge Univ Press, 2017)
Objective:
The cannabinoid receptor 1 (CB1) and transient receptor
potential cation channel subfamily V member 1 (TRPV1) are proposed to
mediate opposite behavioural responses. Their common denominator is the
endocannabinoid ...
Investigating the role of protein kinase-G in the antidepressant-like response of sildenafil in combination with muscarinic acetylcholine receptor antagonism
(Elsevier, 2010)
The cGMP/PK-G pathway plays a crucial role in neuroprotection and neurotrophin support, and is possibly involved in antidepressant action. Recently we reported on a novel antidepressant-like response following simultaneous ...