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Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives
(Elsevier, 2013)
In the present study, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized and evaluated
as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 3,4-dihydro-2(1H)-
quinolinone derivatives ...
Inhibition of monoamine oxidase by selected phenylalkylcaffeine analogues
(Wiley, 2014)
Objectives Caffeine represents a useful scaffold for the design of monoamine
oxidase (MAO) type B inhibitors. Specifically, substitution on the C8 position
yields structures which are high-potency MAO-B inhibitors. To ...
Selected chromone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2012)
A previous study has shown that a series of C6-benzyloxy substituted chromones exhibit high binding affinities for human monoamine oxidase (MAO) B. In an attempt to discover additional chromones with potent and selective ...
Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives
(Elsevier, 2012)
A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...
Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues
(Elsevier, 2012)
In a previous study we have investigated the monoamine oxidase (MAO) inhibitory properties of a series of 8-sulfanylcaffeine analogues. Among the compounds studied, 8-[(phenylethyl)sulfanyl]caffeine (IC50 = 0.223 lM) was ...
Inhibition of monoamine oxidase by selected C6-substituted chromone derivatives
(Elsevier, 2012)
Chromone has been reported to be a useful scaffold for the design of monoamine oxidase (MAO) inhibitors. In an attempt to discover highly potent MAO inhibitors and to contribute to the known structureeactivity relationships ...
Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase
(Elsevier, 2011)
In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for ...
Structural exploration of synthetic chromones as selective MAO-B inhibitors: a mini review
(Bentham Science, 2017)
Aim and Objective: Specific inhibitors of monoamine oxidase (MAO)-B are considered useful therapeutic agents in targeting neurological disorders like Alzheimer's and Parkinson's diseases. Due to the academic challenge of ...
C6- and C7-substituted 3,4-dihydro-2(1H)-quinolinones as inhibitors of monoamine oxidase
(Thieme, 2017)
Purpose Monoamine oxidase (MAO) inhibitors are considered to be useful therapeutic agents and isoform specific inhibitors are employed for the treatment of depression and Parkinson’s disease. MAO inhibitors are also under ...
Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties
(Elsevier, 2014)
Aims: The phenothiazinium compound, methylene blue (MB), possesses diverse pharmacological actions and is
attracting attention for the treatment of bipolar disorder and Alzheimer's disease. MB acts on both monoamine
oxidase ...