Now showing items 1-6 of 6
Evaluation of natural and synthetic 1,4-naphthoquinones as inhibitors of monoamine oxidase
Previous reports have documented that 1,4-naphtho- quinones act as inhibitors of the monoamine oxidase (MAO) enzymes. In particular, fractionation of the extracts of cured tobacco leafs has led to the charac- terization ...
3-Coumaranone derivatives as inhibitors of monoamine oxidase
(Dove Press, 2015)
The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone ...
The synthesis and evaluation of C7-substituted α-tetralone derivatives as inhibitors of monoamine oxidase
Based on a previous report that α-tetralone (3,4-dihydro-2H-naphthalen-1-one) is a promising scaffold for the design of highly potent inhibitors of the enzyme, monoamine oxidase, the present study investigates the monoamine ...
Monoamine oxidase inhibitory activities of heterocyclic chalcones
Studies have shown that natural and synthetic chalcones (1,3-diphenyl-2-propen-1-ones) possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the present study is a report that a series of ...
The inhibition of monoamine oxidase by esomeprazole
Virtual screening of a library of drugs has suggested that esomeprazole, the S-enantiomer of omeprazole, may possess binding affinities for the active sites of the monoamine oxidase (MAO) A and B enzymes. Based on this ...
The interactions of caffeine with monoamine oxidase
Aims: Caffeine has been used as a scaffold for the design of inhibitors of monoamine oxidase (MAO) A and B. Substitution at the C8 position with a variety of moieties yields structures with high MAO inhibition ...