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Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives
Recent studies have found that phthalonitrile derivatives are remarkably potent inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to further determine the structure-activity relationships (SARs) for MAO ...
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B
It has recently been reported that nitrile containing compounds frequently act as potent monoamine oxidase B (MAO-B) inhibitors. Modelling studies suggest that this high potency inhibition may rely, at least in part, on ...