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The nature of relapse in schizophrenia
(BioMed Central, 2013)
Background: Multiple relapses characterise the course of illness in most patients with schizophrenia, yet the nature of these episodes has not been extensively researched and clinicians may not always be aware of important ...
Blunted neuro-endocrine responses linking depressive symptoms and ECG left ventricular hypertrophy in black Africans: the SABPA study
(Wolters Kluwer, 2014)
Objective: Chronic psychosocial stress as experienced in an urban environment plays an important role in the aetiology of depression-related cardiovascular risk. It is uncertain whether acute mental stress responses aggravate ...
Depression, cardiometabolic function and left ventricular hypertrophy in African men and women: the SABPA study
(Taylor & Francis, 2013)
Depressive symptoms are associated with an increased risk for developing cardiovascular diseases, driven by its link to the metabolic syndrome (MetS). This phenomenon, however, still needs to be investigated in the African ...
The α2C-adrenoceptor antagonist, ORM-10921, has antipsychotic-like effects in social isolation reared rats and bolsters the response to haloperidol
(Elsevier, 2016)
Early studies suggest that selective α2C-adrenoceptor (AR)-antagonism has anti-psychotic-like and pro-cognitive properties. However, this has not been demonstrated in an animal model of schizophrenia with a neurodevelopmental ...
Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): response to chronic escitalopram treatment and basal serotonin transporter (SERT) density
(Elsevier, 2013)
Obsessive-compulsive disorder (OCD) is characterized by recurrent thoughts and repetitive motor actions. Hyposerotonergic signalling in the cortico-striatal circuitry is believed to be central to the pathology of OCD, while ...
Excessive nest building is a unique behavioural phenotype in the deer mouse model of obsessive-compulsive disorder
(Sage, 2016)
Obsessive–compulsive disorder (OCD) is a phenotypically heterogeneous condition characterised by time-consuming intrusive thoughts and/or
compulsions. Irrespective of the symptom type diagnosed, the severity of OCD is ...
Depression symptoms facilitated fibrinolytic dysregulation and future coronary artery disease risk in a black male cohort: the sympathetic activity and ambulatory blood pressure in Africans study
(Wolters Kluwer, 2017)
Background: Hypercoagulation is associated with coronary artery disease (CAD). Whether depression symptoms dysregulate inflammatory and hemostatic markers in an African cohort is not known; therefore, we assessed the ...
Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA study
(Elsevier, 2016)
Background
Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD). Whether depression and NO levels will disturb retinal haemodynamics is not clear.
Objectives ...
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates
(Associação Brasileira de Psiquiatria (ABP), 2016)
Objective: In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important.
Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist
on genetic associations. ...
Social behavior in deer mice as a novel interactive paradigm of relevance for obsessive-compulsive disorder (OCD)
(Taylor & Francis, 2017)
Greater obsessive-compulsive (OC) symptom severity may be associated with poor social adjustment. Rather than possessing deficits in social skill per se, OCD patients may be more socially isolative in the presence of normal ...