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C2-substituted quinazolinone derivatives exhibit A1 and/or A2A adenosine receptor affinities in the low micromolar range
(Elsevier, 2020)
Antagonists of the adenosine receptors (A1 and A2A subtypes) are widely researched as potential drug candidates for their role in Parkinson’s disease-related cognitive deficits (A1 subtype), motor dysfunction (A2A subtype) ...
Synthesis and structure activity relationships of chalcone based benzocycloalkanone derivatives as adenosine a 1 and/or a 2a receptor antagonists
(Thieme, 2020)
Adenosine A1 and/or A2A receptor antagonists hold promise for the potential treatment of neurological conditions, such as Parkinson’s disease. Herein, a total of seventeen benzocycloalkanone derivatives were synthesised ...
The new wave of Asia: a message from the president of the International Society of Hypertension
(Wiley, 2020)
Globally, raised blood pressure is the leading risk factor accountable for over 10.4 million deaths per year.1 The cardiovascular consequences of hypertension are devastating, which is why raised blood pressure requires ...
2020 International Society of Hypertension global hypertension practice guidelines
(AHA, 2020)
Context and Purpose of This Guideline
Statement of Remit
To align with its mission to reduce the global burden of raised
blood pressure (BP), the International Society of Hypertension
(ISH) has developed worldwide ...
Naturalistic operant responses in deer mice (Peromyscus maniculatus bairdii) and its response to outcome manipulation and serotonergic intervention
(Wolters Kluwer, 2020)
Investigating the motivational triggers underlying naturalistic compulsive-like behavior is generally regarded as challenging. To this extent, the current study aimed to establish a proof-of-concept for future investigation ...
Asymmetric dimethylarginine and l-homoarginine prospectively relate to carotid wall thickness in a South African cohort
(Springer, 2020)
Background and aims
The L-arginine derivatives asymmetric (ADMA) and symmetric dimethylarginine (SDMA), as well as L-homoarginine may have opposing effects in the pathogenesis of atherosclerosis. We aimed to investigate ...
Athletic-ideal internalisation: lived experiences of female students
(NWU, 2020)
Research has shown a clear relationship between the thin-ideal internalisation, disturbed eating and body-related disturbances. With regard to athletic internalisation, the relationship with these outcomes appears to be ...
Association of dairy consumption with metabolic syndrome, hypertension and diabetes in 147 812 individuals from 21 countries
(BMJ, 2020)
Objective Our aims were to assess the association of
dairy intake with prevalence of metabolic syndrome (MetS)
(cross-sectionally) and with incident hypertension and
incident diabetes (prospectively) in a large ...
Inflammation and salt in young adults: the African-PREDICT study
(Springer, 2020)
Purpose
Low-grade inflammation and a diet high in salt are both established risk factors for cardiovascular disease. High potassium (K+) intake was found to counter increase in blood pressure due to high salt intake and ...
National expenditure on health research in South Africa: how has the landscape changed in the past decade?
(Health & Medical Publishing Group, 2020)
Background. Over the past 18 years, the South African (SA) Ministry of Health has committed to allocate 2% of the national health budget to research, while the National Health Research Policy (2001) proposed that the health ...