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Mechanical and physical behavior of fibrin clot formation and lysis in combined oral contraceptive users
(Cambridge Univ Press, 2020)
Combined oral contraceptives (COCs) are commonly prescribed and increase the risk of venous thromboembolism (VTE). We have previously found that two COCs, both containing drospirenone (DRSP) and ethinyl estradiol (EE), ...
In vivo evaluation of acute intravenous toxicity of a [Ga-68]Ga-PSMA-11-microemulsion
(Elsevier, 2020)
Microemulsions (MEs) are reported to improve the efficacy of a drug, minimise side effects and toxicity of the encapsulated compound. MEs are hypothesized to aid in making the encapsulated compound, which has been incorporated ...
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
(Springer Nature, 2020)
Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative ...
Methylene blue analogues: in vitro antimicrobial minimum inhibitory concentrations and in silico pharmacophore modelling
(Elsevier, 2020)
It has been shown that methylene blue has antimicrobial properties although few studies have determined its minimum inhibitory concentration (MIC), which is the gold standard used to measure antimicrobial activity. The ...
COVID-19 across Africa: epidemiologic heterogeneity and necessity of contextually relevant transmission models and intervention strategies
(American College of Physicians, 2020)
Coronavirus disease 2019 (COVID-19) has rapidly emerged as a global public health threat with epicenters in regions of China, parts of Europe, and larger urban centers across North America (1). By comparison, population-level ...
Metronidazole-conjugates: a comprehensive review of recent developments towards synthesis and medicinal perspective
(Elsevier, 2020)
Nitroimidazoles based compounds remain a hot topic of research in medicinal chemistry due to their numerous biological activities. Moreover, many clinical candidates based on this chemical core have been reported to be ...
Diet and sedentary behaviour in relation to mortality in US adults with a cardiovascular condition: results from the National Health and Nutrition Examination Survey linked to the US mortality registry
(Cambridge Univ Pess, 2020)
CVD is the most common chronic condition and the highest cause of mortality in the USA. The aim of the present work was to investigate diet and sedentary behaviour in relation to mortality in US CVD survivors. The National ...
Reflections on the OECD guidelines for in vitro skin absorption studies
(Elsevier, 2020)
At the 8th conference of Occupational and Environmental Exposure of the Skin to Chemicals (OEESC) (16–18 September 2019) in Dublin, Ireland, several researchers performing skin permeation assays convened to discuss in vitro ...
The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine
(Elsevier, 2020)
We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated ...
Towards a methodology for online VR application testing
(IEEE, 2020)
Performing online testing for applications is a common practice in business, but for research without much control over the participants it is unknown as to what this process should look like and what could be possible ...