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Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy
(Elsevier, 2012)
Malaria and HIV are among the most important global health problems of our time and together are responsible for approximately 3 million deaths annually. These two diseases overlap in many regions of the world including ...
Synthesis and antimalarial activity of ethylene glycol oligomeric ethers of artemisinin
(Wiley, 2011)
Objectives The aim of this study was to synthesize a series of ethylene glycol ether derivatives of the antimalarial drug artemisinin, determine their values for selected physicochemical properties and evaluate their ...
Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids
(Elsevier, 2011)
Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids 9–14, which were then treated with oxalic acid to form oxalate salts (9a–14a). Compounds 9a, 10a, 12, 12a, and 14a showed comparable ...
Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin
(Elsevier, 2012)
In this study, a series of 11 10-aminoethylether derivatives of artemisinin were synthesised and their
antimalarial activity against both the chloroquine sensitive (D10) and resistant (Dd2) strains of Plasmodium
falciparum ...
Synthesis and antimalarial activity of ethylene glycol oligomeric ethers of artemisinin
(Wiley, 2011)
Objectives The aim of this study was to synthesize a series of ethylene glycol ether
derivatives of the antimalarial drug artemisinin, determine their values for selected physicochemical
properties and evaluate their ...
In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum
(Springer Nature, 2012)
The macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been demonstrated. In this study, we investigated the enhancement of the ...
Synthesis and in vitro biological activities of ferrocenyl-chalcone amides
(Springer, 2016)
A series of aminoferrocenyl–chalcone amides 11–19 were synthesized through condensation of a carboxylic acid-functionalized chalcone 10 with ferrocenylamines, using 1,1′-carbonyldiimidazole as the coupling agent. The ...
Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids
(Elsevier, 2013)
The aim of this study was to synthesize a series of quinoline–pyrimidine hybrids and to evaluate their
in vitro antimalarial activity as well as cytotoxicity. The hybrids were brought about in a two-step nucleophilic
s ...
Synthesis and in vitro biological evaluation of aminoacridines and artemisinin-acridine hybrids
(Elsevier, 2014)
During this study, 9-aminoacridine and artemisinin–acridine hybrid compounds were synthesized and the in vitro for antimalarial activity against both the chloroquine sensitive but also gametocytocidal strain (NF54), and ...
Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities
(Elsevier, 2016)
As part of a programme aimed at identifying rational new triple drug combinations for treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one component, given that selected examples exhibit ...