Now showing items 31-40 of 122
The association between anthopometric parameters, the metabolic syndrome and microalbuminuria in black Africans: The SABPA study
(Clinics Cardive Publishing Ltd, 2010)
Adipokines and cardiometabolic function: how are they interlinked?
Objective Adipokines contribute directly to the coexistence of insulin resistance and endothelial dysfunction. Most studies focus on a single adipokine. We therefore investigated the independent relationships of leptin, ...
Die belewing van betekenisvolheid deur 'n groep Suid-Afrikaners
(Pretoria : Suid-Afrikaanse Akademie vir Wetenskap en Kuns, 2010)
Formulation and transdermal delivery of aciclovir and ketoconazole for HIV/AIDS patients
Due to their compromised immune systems, HIV/ AIDS- infected individuals are more susceptible to skin infections. Since fungal and viral cutaneous manifestations are frequently encountered in combination in HIV/AIDS patients, ...
Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues
Based on recent reports that several (E)-8-styrylcaffeinyl analogues are potent reversible inhibitors of monoamine oxidase B (MAO-B), a series of 8-benzyloxycaffeinyl analogues were synthesized and evaluated as inhibitors ...
Artemisinin quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity
Novel artemisinin–quinoline hybrid-dimers were synthesized from dihydroartemisinin and different aminoquinolines at elevated temperatures (90–110 °C). All compounds were obtained as the β-isomers and were tested against ...
In-vitro transdermal penetration of cytarabine and its N4-alkylamide derivatives
Objectives The aim of this study was to synthesise and determine the transdermal penetration of cytarabine alkylamide derivatives and assess the correlation of flux with physicochemical properties. Methods The alkylamide ...
Euphorbias of South Africa: two new phorbol esters from Euphorbia bothae
(South African Bureau for Scientific Publications, 2010)
Two known phorbol esters, 12-deoxyphorbol-13-isobutyrate-20-acetate (1) and 12-deoxyphorbol-13-(2-methylbutyrate)-20-acetate (2), and two new phorbol esters, 12-deoxyphorbol-13-isobutyrate-16-angelate-20-acetate (3) and ...
A significant decline in IGF-I may predispose young Africans to subsequent cardiometabolic vulnerability
(Oxford Univ Press, 2010)
Objectives: Low serum IGF-I is an independent risk factor for diabetes and cardiovascular disease. These noncommunicable diseases are extremely common in urban black South Africans, but their IGF-I concentration is unknown. ...
Channel inclusion of primary alcohols in isostructural solvates of the antiretroviral nevirapine: an X-ray and thermal analysis study
X-ray structural and thermoanalytical data for a series of solvates 2–7 of the anti-HIV drug nevirapine containing primary alcohols CH3(CH2)nOH with n = 2–7 are reported. The structures of 2–7 are based on a common ...