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Mind your state: insights into antidepressant nonadherence
(MedPharm Publications, 2016)
Major depressive disorder (MDD) is an insidious disease and affects up to 15% of the global population. Although MDD responds
to a wide range of pharmacological treatment options, a number of factors, i.e. not adhering ...
Carbon-14 radiolabelling and tissue distribution evaluation of a potential anti-TB compound
(Wiley, 2016)
This paper describes a five-step synthesis of a carbon-14-labelled pyrazole compound (11). A total of 2.96 MBq of 11 was obtained with the specific activity of 2242.4 MBq/mmol. The radiochemical purity was >99%, and the ...
Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression
(Springer, 2016)
Rationale
The mechanisms mediating ketamine’s antidepressant effect have only been partly resolved. Recent preclinical reports implicate serotonin (5-hydroxytryptamine; 5-HT) in the antidepressant-like action of ketamine. ...
Essential fatty acids as transdermal penetration enhancers
(Elsevier, 2016)
The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ...
In vitro skin permeation of artemisone and its nano-vesicular formulations
(Elsevier, 2016)
The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid
lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such
formulations ...
Exploratory data analysis of the dependencies between skin permeability, molecular weight and log P
(Govi-Verlag, 2016)
Molecular weight and log P remain the most frequently used physicochemical properties in models that predict skin permeability. However, several reports over the past two decades have suggested that predictions made by ...
Mental health services in South Africa
(Nova Science publishers, 2016)
The mental-health conditions and services in most African countries are of great concern. There is a stark distinction of health disparities between urban and rural communities across these countries. There is an unequal ...
Internal and external match loads of university-level soccer players: a comparison between methods
(Lippincott, Williams & Wilkins, 2016)
The aim of this study was to use individualized intensity zones to compare the external (velocity and Player Load, PL) and internal loads (heart rate, HR) of a cohort of university-level soccer players. Thirteen soccer ...
The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study
(Springer, 2016)
Inadequate substrate availability and increased
nitric oxide synthase inhibitor levels attenuate nitric oxide
(NO) synthesis, whereas increased vascular oxidative
stress may lead to inactivation of NO. We compared
markers ...
Promoting food security through indigenous and traditional food crops
(Taylor & Francis, 2016)
Despite many factors weighing in South Africa’s favor on the agricultural front, including having official “food secure” status, millions of households have insufficient access to nutritionally safe food. This is largely ...