Now showing items 51-60 of 2162
The health benefits and constraints of exercise therapy for wheelchair users: a clinical commentary
Background: There are approximately 1 billion people living with chronic lower limb disability, many of whom are wheelchair users. Objectives: Review cardiometabolic and neuromuscular risk profiles of wheelchair ...
DNA damage and repair capacity in hairdressers exposed to chemical products: a pilot study
Hairdressers are exposed to numerous hazardous chemical substances, some of which are known or suspected allergens, carcinogens or organic solvents. The objectives of this study were to compare DNA damage and DNA repair ...
Maximum potential cost-savings attributable to generic substitution of antipsychotics 2008 to 2013
Background Schizophrenia is a costly illness to treat, especially during a time of escalating medicine inflation costs, putting a large economic strain on patients, their families and the community. Treatment, however, ...
Adjustments to the preanalytical phase of quantitative cell-free DNA analysis
Evaluating the kinetics of cell-free DNA (cfDNA) in the blood of cancer patients could be a strong auxiliary component to the molecular characterization of cfDNA, but its potential clinical significance is obscured by the ...
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease
A series of 7-substituted coumarin derivatives were designed and synthesised to display ChE and MAO-B inhibitory activity. The compounds consisted out of a coumarin structure (MAO-B inhibitor) and benzyl-, piperidine-, ...
Interactions of the antimicrobial peptide nisin Z with conventional antibiotics and the use of nanostructured lipid carriers to enhance antimicrobial activity
Antimicrobial resistance is an imminent threat to the effective prevention and treatment of bacterial infections and alternative antimicrobial strategies are desperately needed. Antimicrobial peptides (AMPs) may be promising ...
The centrality of the research question for locating PhD studies in the global knowledge society
(University of Stellenbosch, 2014)
Although classified as a developing country, South Africa lags far behind other BRICS member countries. A cause for concern is that the number of PhD studies rather than what they contribute is often used to measure their ...
Selected C8 two-chain linkers enhance the adenosine A1/A2A receptor affinity and selectivity of caffeine
Recent research exploring C8 substitution on the caffeine core identified 8-(2-phenylethyl)-1,3,7-trimethylxanthine as a non-selective adenosine receptor antagonist. To elaborate further, we included various C8 two-chain-length ...
Elimination of Schistosoma mansoni in infected mice by slow release of artemisone
The current treatment of schistosomiasis is based on the anti-helminthic drug praziquantel (PZQ). PZQ affects only the adult stages of schistosomes. In addition, resistance to PZQ is emerging. We suggest a drug, which ...
Dietary sodium and cardiovascular disease risk
(Massachusetts Medical Society, 2016)