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Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites
(Nature, 2018)
The quinolone decoquinate is coadministered with feed for treatment of parasites which cause coccidiosis in poultry. However, from a drug-development perspective, the biological activity is often not adequately exploited ...
Recent progress in the development of anti-malarial quinolones
(BioMed Central, 2014)
Available anti-malarial tools have over the ten-year period prior to 2012 dramatically reduced the number of fatalities
due to malaria from one million to less than six-hundred and thirty thousand. Although fewer people ...
Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities
(Elsevier, 2016)
As part of a programme aimed at identifying rational new triple drug combinations for treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one component, given that selected examples exhibit ...