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The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine
(Elsevier, 2020)
We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated ...
A critical role of mitochondria in BDNF-associated synaptic plasticity after one-week vortioxetine treatment
(Oxford Univ Press, 2018)
Background
Preclinical studies have indicated that antidepressant effect of vortioxetine involves increased synaptic plasticity and promotion of spine maturation. Mitochondria dysfunction may contribute to the pathophysiological ...