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Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites
The quinolone decoquinate is coadministered with feed for treatment of parasites which cause coccidiosis in poultry. However, from a drug-development perspective, the biological activity is often not adequately exploited ...
Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives
Tuberculosis is the deadliest infectious disease affecting humankind with a death toll of approximately 1.7 million people in 2016. The increasing prevalence of multidrug‐resistant strains of the causative pathogen, ...
Synthesis and antimycobacterial activity of disubstituted benzyltriazoles
The increasing prevalence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), the pathogen of human tuberculosis (TB), serves as a strong incentive for the discovery and development of new agents for the ...
Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues
The emergence of drug-resistant tuberculosis (DR-TB) as well as the requirement for long, expensive and toxic drug regimens impede efforts to control and eliminate TB. Therefore, there’s a need for effective and affordable ...
Synthesis and in vitro antimycobacterial and antileishmanial activities of hydroquinone-triazole hybrids
Infectious diseases such as tuberculosis and leishmaniasis are leading causes of human death. One of the major factors contributing to the poor control of these diseases is primarily the reduced effectiveness of the existing ...