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Synthesis and in vitro biological activities of ferrocenyl-chalcone amides
A series of aminoferrocenyl–chalcone amides 11–19 were synthesized through condensation of a carboxylic acid-functionalized chalcone 10 with ferrocenylamines, using 1,1′-carbonyldiimidazole as the coupling agent. The ...
Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities
As part of a programme aimed at identifying rational new triple drug combinations for treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one component, given that selected examples exhibit ...
Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin
In an attempt to improve the efficacy and stability of current, clinically used artemisinins, a series non-hemiacetal ester derivatives of artemisinin were synthesized and evaluated for their in vitro antiplasmodial and ...
Cell based assays for anti-Plasmodium activity evaluation
Malaria remains one of the most common and deadly infectious diseases worldwide. The severity of this global public health challenge is reflected by the approximately 198 million people, who were reportedly infected in ...