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Leptin and its relation to autonomic activity, endothelial cell activation and blood pressure in a young black and white population: the African-PREDICT study
(Thieme, 2018)
An increasing prevalence of obesity-related hypertension is observed in the youth and may have severe consequences for future cardiovascular disease development. Previous studies portrayed leptin as a potential factor ...
Retinal vessel calibres and haemostasis in black and white South Africans: the SABPA study
(Lippincott Williams & Wilkins, 2015)
Objectives: Retinal arteriolar narrowing associates with hypertension development and indicates increased cardiovascular risk. Evidence on whether the retinal vessel "calibres are related to the haemostatic system is ...
Cornell product relates to albuminuria in hypertensive black adults independently of blood pressure: the SABPA study
(Elsevier, 2015)
Evidence of the relationship between left ventricular hypertrophy and urinary albumin excretion is contradictory and limited in black adults in whom hypertensive heart disease is common. We aimed to investigate the ...
Low testosterone and hyperkinetic blood pressure responses in a cohort of South African men: the SABPA study
(Taylor & Francis, 2013)
Hypertension (HT) and the metabolic syndrome are major problems in Africa. The role of sex hormones in the cardiovascular profile of black Africans in South Africa has not been studied. Our objective was to study the ...
The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study
(Springer, 2016)
Inadequate substrate availability and increased
nitric oxide synthase inhibitor levels attenuate nitric oxide
(NO) synthesis, whereas increased vascular oxidative
stress may lead to inactivation of NO. We compared
markers ...
The cardiotonic steroid marinobufagenin is a predictor of increased left ventricular mass in obesity: the African-PREDICT study
(MDPI, 2020)
The endogenous Na+/K+-ATPase inhibitor, marinobufagenin (MBG), strongly associates with salt intake and a greater left ventricular mass index (LVMi) in humans and was shown to promote cardiac fibrosis and hypertrophy in ...
Large artery stiffness is associated with marinobufagenin in young adults: the African-PREDICT study
(Wolters Kluwer, 2018)
Objectives: The cardiotonic steroid, marinobufagenin (MBG), has been shown to play a physiological natriuretic role in response to salt intake. However, recent studies in clinical and animal models demonstrated possible ...
The African prospective study on the early detection and identification of cardiovascular disease and hypertension (African-PREDICT): design, recruitment and initial examination
(Sage, 2019)
Background: Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of hypertension remains on an
increase. Although this might be attributed to poor healthcare and ineffective antihypertensive ...
Retinal vessel caliber and caliber responses in true normotensive black and white adults: the African-PREDICT study
(Elsevier, 2020)
Purpose
Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis ...
Von Willebrand factor, its cleaving protease (ADAMTS13), and inflammation in young adults: the African-PREDICT study
(Elsevier, 2020)
Background
The role of inflammation in the early development of vascular dysfunction remains complex. Interleukin-6 (IL-6) and C-reactive protein (CRP) can cause an acute imbalance in the von Willebrand factor (vWF)-ADAMTS13 ...