Now showing items 1-4 of 4
A gene-environment study of cytoglobin in the human and rat hippocampus
Background: Cytoglobin (Cygb) was discovered a decade ago as the fourth vertebrate heme-globin. The function of Cygb is still unknown, but accumulating evidence from in vitro studies point to a putative role in scavenging ...
Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment
Depressive disorders and the treatment thereof have been associated with a number of neuroplastic events, such as neurogenesis and synaptic remodeling in discrete areas of the brain. The associations of these events in ...
The Flinders sensitive line rat model of depression: 25 years and still producing
Approximately 25 years have passed since the first publication suggesting the Flinders sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on these rats was completed before that seminal ...
The current development of CNS drug research
(Oxford Univ Press, 2013)
In the past few years, several high profiled pharmaceutical companies have decided to shut down major research activities within the central nervous system (CNS) area. For example, in December 2011 Novartis announced ...