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Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: effect of ketamine
(Wiley, 2017)
Major depressive disorder (MDD) is associated with dysfunctional serotonergic and glutamatergic neurotransmission, and the genetic animal model of depression Flinders Sensitive Line (FSL) rats display alterations in these ...
S-ketamine rapidly reverses synaptic and vascular deficits of hippocampus in genetic animal model of depression
(Oxford Univ Press, 2017)
Background:
The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce a rapid antidepressant effect within hours. In ...
The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex
(Elsevier, 2017)
It is well established that stress plays a major role in the pathogenesis of neuropsychiatric diseases. Stress-induced alteration of synaptic plasticity has been hypothesized to underlie the morphological changes observed ...
Systematic evaluation of skeletal fractures caused by induction of electroconvulsive seizures in rat state a need for attention and refinement of the procedure
(Cambridge Univ Press, 2017)
Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects ...
Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats
(Elsevier, 2017)
The rapid and sustained antidepressant properties of ketamine provide evidence of the importance of the glutamatergic system in the neurobiology of depression. The antidepressant-like effects of ketamine are dependent on ...
Discovery versus implementation research on mental disorders in low- and middle-income countries. Editorial
(Cambridge Univ Press, 2017)
The 10/90 research gap refers to the fact that only
10% of the world’s research resources are spent in lowand
middle-income countries (LMICs) although 90%
of preventable deaths occur in these regions: similar
disparities ...
A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats
(Cambridge Univ Press, 2017)
Objective:
The cannabinoid receptor 1 (CB1) and transient receptor
potential cation channel subfamily V member 1 (TRPV1) are proposed to
mediate opposite behavioural responses. Their common denominator is the
endocannabinoid ...
Probiotic treatment reduces depressive-like behaviour in rats independently of diet
(Elsevier, 2017)
The gut microbiota has recently emerged as an important regulator of brain physiology and behaviour in animals, and ingestion of certain bacteria (probiotics) therefore appear to be a potential treatment for major depressive ...
Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus
(Wiley, 2017)
Background and purpose
Astroglia contribute to the pathophysiology of major depression and antidepressant drugs act by modulating synaptic plasticity; therefore, the present study investigated whether the fast antidepressant ...
Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats
(Elsevier, 2017)
Major depressive disorder (MDD) is highly associated with dysmetabolic conditions, such as obesity and diabetes mellitus type 2, and the gut microbiota may interact with both disease entities. We have previously shown that ...