Search
Now showing items 1-10 of 11
Is the cardiovascular health of South Africans today comparable with African Americans 45 years ago?
(Wolters Kluwer, 2019)
Objectives: Hypertension occurs frequently among
black populations around the world. In the United
States (US) health system, interventions since the 1960s
resulted in improvements in hypertension awareness,
management ...
Left ventricular mass independently associates with 24-hour sodium excretion in young masked hypertensive adults: the African-PREDICT study
(Elsevier, 2019)
Background
Due to the known contribution of excess sodium intake on elevations in blood pressure, salt reduction regulations are being introduced in countries all over the world. To study the contribution of sodium intake ...
Plasminogen activator inhibitor-1 activity and the 4G/5G polymorphism are prospectively associated with blood pressure and hypertension status
(Wolters Kluwer, 2019)
Objectives:
Plasminogen activator inhibitor-1 (PAI-1) has consistently shown positive associations with blood pressure (BP). Whether elevations in PAI-1 levels precede or result from raised BP is still under debate and ...
The association of measures of the micro- and macro-vasculature with selenium and GPx activity in a young bi-ethnic population: the African-PREDICT study
(Taylor & Francis, 2019)
Objective: Selenium plays an important physiological role as component for antioxidant selenoproteins such as glutathione peroxidase (GPx). Since oxidative stress contributes to hypertension development, it is likely that ...
A call for improved reporting on serious adverse events in clinical trials
(Wolters Kluwer, 2019)
Following SPRINT (Systolic Blood Pressure Intervention Trial) [1], several investigations including systematic reviews and meta-analyses confirmed that reducing SBP to levels below 140 mmHg markedly reduces the risk of ...
Fixed-dose combination antihypertensive medications
(Elsevier, 2019)
On July 9, 2019, WHO added fixeddose combination antihypertensive
medications to the WHO Essential
Medicines List. Treatment with fixeddose combination medicines, also
known as single-pill combinations,
is the emerging ...
Aldosterone and renin in relation to surrogate measures of sympathetic activity: the SABPA study
(Clinics Cardive Publishing, 2019)
Introduction: Hypertension, particularly in black populations, is often accompanied by augmented sympathetic nervous system activity and suppressed renin activity, indicative of possible blood pressure (BP) dysregulation. ...
Assessing tobacco use in an African population: serum and urine cotinine cut-offs from South Africa
(Elsevier, 2019)
Background
Cotinine, a nicotine metabolite, is used to measure tobacco use and exposure, but recommended cut-offs to differentiate tobacco users from those exposed through the environment range from 3 to 58 ng/ml in serum, ...
Iron loading, alcohol and mortality: a prospective study
(Elsevier, 2019)
Background & aims
The relationship between total body iron and cardiovascular disease remains controversial and information absent in black sub-Saharan Africans in whom alcohol consumption tends to be high. The level of ...
The Na+K+-ATPase inhibitor marinobufagenin and early cardiovascular risk in humans: a review of recent evidence
(Springer, 2019)
Purpose of Review
This review synthesizes recent findings in humans pertaining to the relationships between marinobufagenin (MBG), a steroidal Na+/K+-ATPase inhibitor and salt-sensitivity biomarker, and early cardiovascular ...