Now showing items 1-10 of 250
Differential expression of postsynaptic NMDA and AMPA receptor subunits in the hippocampus and prefrontal cortex of the flinders sensitive line rat model of depression
Glutamatergic abnormalities have recently been implicated in the pathophysiology of depression, and the ionotropic glutamate receptors in particular have been suggested as possible underlying molecular determinants. The ...
Report of the International Society of Hypertension Teaching Seminar organized by the International Society of Hypertension Africa Regional Advisory Group: Maputo, Mozambique, 2016
(Wolters Kluwer, 2016)
The International Society of Hypertension (ISH), in fulfilment of its mission of promoting hypertension control and prevention and also of advancing knowledge globally, organizes hypertension teaching seminars or ‘summer ...
Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus
Preclinical studies reveal that the multimodal antidepressant vortioxetine enhances long-term potentiation and dendritic branching compared to a selective serotonin reuptake inhibitor (SSRI). In the present study, we ...
Role of novel drug delivery systems in bioavailability enhancement: at a glance
(DYR Labs, 2016)
Novel drug delivery systems (NDDS) are one of the most strategies which enable to overcome the problems related to drug bioavailability. It is the rate and extent to which a drug becomes available to the target tissue after ...
Potential involvement of serotonergic signaling in ketamine's antidepressant actions: a critical review
A single i.v. infusion of ketamine, classified as an N-methyl-d-aspartate (NMDA) receptor antagonist, may alleviate depressive symptoms within hours of administration in treatment resistant depressed patients, and the ...
Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
Background Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns ...
A novel RP-HPLC method for the detection and quantification of clarithromycin or spiramycin in bulk drug samples and dosage forms
(Innovare Academic Sciences, 2016)
Objective: This study was aimed at developing an HPLC method that would be suitable and sufficiently robust to analyze clarithromycin or spiramycin from bulk materials, amorphous solid dispersions as well as when included ...
Maximum potential cost-savings attributable to generic substitution of antipsychotics 2008 to 2013
Background Schizophrenia is a costly illness to treat, especially during a time of escalating medicine inflation costs, putting a large economic strain on patients, their families and the community. Treatment, however, ...
Adjustments to the preanalytical phase of quantitative cell-free DNA analysis
Evaluating the kinetics of cell-free DNA (cfDNA) in the blood of cancer patients could be a strong auxiliary component to the molecular characterization of cfDNA, but its potential clinical significance is obscured by the ...
Dietary sodium and cardiovascular disease risk
(Massachusetts Medical Society, 2016)