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Synthesis and in vitro antileishmanial efficacy of benzyl analogues of nifuroxazide
(Wiley, 2020)
Leishmaniasis is a vector‐borne parasitic disease that mostly affects populations in tropical and subtropical countries. There is currently no vaccine to protect against and only a handful of drugs are available to treat ...
Inhibitory effects of novel ciprofloxacin derivatives on the growth of four Babesia species and Theileria equi
(Springer, 2020)
The problems of parasite resistance, as well as the toxic residues to most of the commercially available antipiroplasmic drugs severely weaken their effective, curative, and environmental safe employment. Therefore, it is ...
Synthesis and in vitro antimycobacterial and antileishmanial activities of hydroquinone-triazole hybrids
(Springer, 2020)
Infectious diseases such as tuberculosis and leishmaniasis are leading causes of human death. One of the major factors contributing to the poor control of these diseases is primarily the reduced effectiveness of the existing ...
Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues
(Elsevier, 2020)
The emergence of drug-resistant tuberculosis (DR-TB) as well as the requirement for long, expensive and toxic drug regimens impede efforts to control and eliminate TB. Therefore, there’s a need for effective and affordable ...
Recent advances in the synthesis and development of nitroaromatics as anti-infective drugs
(Bentham Science, 2020)
Infectious diseases commonly occur in tropical and sub-tropical countries. The pathogens of such diseases are able to multiply in human hosts, warranting their continual survival. Infections that are commonplace include ...
Synthesis and in vitro antileishmanial efficacy of novel quinazolinone derivatives
(Wiley, 2020)
Currently available drugs being used to treat leishmaniasis have several shortcomings, including high toxicity, drug administration that requires hospitalization, and the emergence of parasite resistance against clinically ...
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes
(Elsevier, 2020)
Leishmaniasis is a neglected tropical disease affecting thousands worldwide, especially in developing countries where it co-exists with malaria. Only a handful of drugs are clinically available to treat the disease, but ...