Now showing items 1-10 of 35
Autonomic activity and its relationship with the endogenous cardiotonic steroid marinobufagenin: the African-PREDICT study
(Taylor & Francis, 2020)
Aim: Marinobufagenin (MBG), a cardiotonic steroid and a natriuretic hormone, is elevated in response to high salt diet consumption. In animal models salt intake stimulates adrenocortical MBG secretion via increased angiotensin ...
Prediction of 24-hour sodium excretion from spot urine samples in South African adults: a comparison of four equations
Repeated 24-hour urine collection is considered to be the gold standard for assessing salt intake. This is often impractical in large-population studies, especially in low–middle-income countries. Equations to estimate ...
Inflammation and salt in young adults: the African-PREDICT study
Purpose Low-grade inflammation and a diet high in salt are both established risk factors for cardiovascular disease. High potassium (K+) intake was found to counter increase in blood pressure due to high salt intake and ...
Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study
(Springer Nature, 2020)
Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether ...
Immunity, inflammation and the vasculature in the COVID-19 era. Editorial comment.
(Wolters Kluwer, 2020)
The coronavirus disease 2019 (COVID-19) pandemic not only changed our day-to-day lives abruptly, but it also forced the global scientific community to reevaluate everything that we thought we knew
Methylation vs. protein inflammatory biomarkers and their associations with cardiovascular function
(Frontiers Media, 2020)
DNA methylation data can be used to estimate proportions of leukocyte subsets retrospectively, when directly measured cell counts are unavailable. The methylation-derived neutrophil-to-lymphocyte and lymphocyte-to-monocyte ...
The association of PAI-1 with 24 h blood pressure in young healthy adults is influenced by smoking and alcohol use: the African-PREDICT study
Background and aims The association between plasminogen activator inhibitor-1 (PAI-1) and blood pressure is well established, but it is debatable whether raised PAI-1 levels precede or result from raised blood pressure. ...
Von Willebrand factor, its cleaving protease (ADAMTS13), and inflammation in young adults: the African-PREDICT study
Background The role of inflammation in the early development of vascular dysfunction remains complex. Interleukin-6 (IL-6) and C-reactive protein (CRP) can cause an acute imbalance in the von Willebrand factor (vWF)-ADAMTS13 ...
The cardiotonic steroid marinobufagenin is a predictor of increased left ventricular mass in obesity: the African-PREDICT study
The endogenous Na+/K+-ATPase inhibitor, marinobufagenin (MBG), strongly associates with salt intake and a greater left ventricular mass index (LVMi) in humans and was shown to promote cardiac fibrosis and hypertrophy in ...
Cardiovascular diseases are the major cause of morbidity and mortality worldwide. They develop over long periods of time, and are typically caused by multiple factors, and interaction with the environment. Proteomics allows ...