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The cardiotonic steroid marinobufagenin is a predictor of increased left ventricular mass in obesity: the African-PREDICT study
(MDPI, 2020)
The endogenous Na+/K+-ATPase inhibitor, marinobufagenin (MBG), strongly associates with salt intake and a greater left ventricular mass index (LVMi) in humans and was shown to promote cardiac fibrosis and hypertrophy in ...
Leptin and the retinal microvasculature in young black and white adults: the African-PREDICT study
(Elsevier, 2020)
Background
Leptin is a vasoactive peptide that has been linked to diseases associated with macrovascular deterioration. What is still uncertain is its involvement in the microvasculature. Since microvascular changes are ...
Retinal vessel caliber and caliber responses in true normotensive black and white adults: the African-PREDICT study
(Elsevier, 2020)
Purpose
Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis ...
Von Willebrand factor, its cleaving protease (ADAMTS13), and inflammation in young adults: the African-PREDICT study
(Elsevier, 2020)
Background
The role of inflammation in the early development of vascular dysfunction remains complex. Interleukin-6 (IL-6) and C-reactive protein (CRP) can cause an acute imbalance in the von Willebrand factor (vWF)-ADAMTS13 ...
The Exercise, Arterial Modulation and Nutrition in Youth South Africa Study (ExAMIN Youth SA)
(Frontiers Media, 2020)
Background: The impact of a sedentary and unhealthy lifestyle on cardiovascular
health is well-documented, however the current obesity and hypertension trends among
children is concerning. The ExAMIN Youth SA study aims ...
Heart rate variability, the dynamic nature of the retinal microvasculature and cardiac stress: providing insight into the brain-retina-heart link: the SABPA study + Correction
(Nature, 2020)
Background and aims
Decreased heart-rate-variability (HRV) indicates increased sympathetic nervous system (SNS) activity and modulation with a shift in the sympatho-vagal balance towards SNS predominance. Increased SNS ...
Correction to: Heart rate variability, the dynamic nature of the retinal microvasculature and cardiac stress: providing insight into the brain–retina–heart link: the SABPA study
(Springer, 2020)
Correction to: Eye
https://doi.org/10.1038/s41433-019-0515-y
Since the online publication of this article, the authors have noticed that the conclusion to the abstract contains an error. The correct abstract conclusion ...
Autonomic activity and its relationship with the endogenous cardiotonic steroid marinobufagenin: the African-PREDICT study
(Taylor & Francis, 2020)
Aim: Marinobufagenin (MBG), a cardiotonic steroid and a natriuretic hormone, is elevated in response to high salt diet consumption. In animal models salt intake stimulates adrenocortical MBG secretion via increased angiotensin ...
Microvascular function in non-dippers: potential involvement of the salt sensitivity biomarker, marinobufagenin-the African-PREDICT study
(Wiley, 2020)
Suppressed nighttime blood pressure dipping is associated with salt sensitivity and may increase the hemodynamic load on the microvasculature. The mechanism remains unknown whereby salt sensitivity may increase the ...
Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study
(Springer Nature, 2020)
Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether ...