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Decreased in vivo α2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression
(Elsevier, 2015)
Depression is a debilitating heterogenous disorder and the underlying mechanisms remain elusive. Alterations in monoaminergic neurotransmission, including noradrenergic, have been implicated in the etiology of depression. ...
Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour
(Cambridge Univ Press, 2015)
Objective: Gut microbiota (GM) has previously been associated with alterations in rodent behaviour, and since the GM is affected by the diet, the composition of the diet may be an important factor contributing to behavioural ...
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)
Depressive disorders represent a significant health concern as they are associated with high social and
physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective
treatment ...
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)
Depressive disorders represent a significant health concern as they are associated with high social and
physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective
treatment ...
Isolation-induced behavioural changes in a genetic animal model of depression
(Elsevier, 2012)
Depression is a heterogeneous disorder displaying a range of symptoms including feelings of despair and social withdrawal. Social isolation may complicate the progression of depression and have effects on both behaviour ...
Maternal high-fat diet programs offspring emotional behavior in adulthood
(Elsevier, 2018)
Prenatal exposure to high-fat diet (HFD) might predispose offspring to develop metabolic and mental disorders later in life. Insight into the molecular and behavioral consequences of maternal HFD on offspring is sparse but ...
A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression
(Elsevier, 2011)
Major depressive disorder (MDD) and diabetes mellitus type II (T2DM) are two of the major health challenges of our time. It has been shown that MDD and T2DM are highly co-morbid, and recent work has proposed a bi-directional ...
Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats
(Elsevier, 2017)
The rapid and sustained antidepressant properties of ketamine provide evidence of the importance of the glutamatergic system in the neurobiology of depression. The antidepressant-like effects of ketamine are dependent on ...
Neurovascular plasticity of the hippocampus one week after a single dose of ketamine in genetic rat model of depression
(Wiley, 2016)
Glutamatergic system and the structural plasticity hypothesis are principal components for rapid and sustained antidepressant effects of novel antidepressant therapeutics. This study represents the first investigation of ...
Antidepressant efficacy of high and low frequency transcranial magnetic stimulation in the FSL/FRL genetic rat model of depression
(Elsevier, 2016)
Repetitive Magnetic Stimulation (rTMS) has appeared to be a potential non-invasive antidepressant method, which implies non-convulsive focal stimulation of the brain through a time varying magnetic field. The antidepressant ...