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Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives
(Elsevier, 2014)
Malaria remains one of the world's most common infectious diseases, being responsible for more deaths than any other communicable disease except tuberculosis. There is strong evidence that tumour necrosis factor α and ...
Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides
(Elsevier, 2014)
A series of 4-aminoquinolinyl-chalcone amides 11–19 were synthesized through condensation of carboxylic
acid-functionalized chalcone with aminoquinolines, using 1,10-carbonyldiimidazole as coupling
agent. These compounds ...
Synthesis, in vitro antiplasmodial and antiproliferative activities of a series of quinoline-ferrocene hybrids
(Springer, 2014)
Series of quinoline–ferrocene hybrids containing
various linkers were synthesized and evaluated for
antimalarial and anticancer activities as well as cytotoxicity.
The hybrids with rigid linkers were found to be ...
Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisininetriazine hybrids and hybrid-dimers
(Elsevier, 2014)
A series of artemisininetriazine hybrids and hybrid-dimers were synthesized and their in vitro antimalarial
activity against the chloroquine sensitive (CQS), the gametocytocidal (NF54) and the choroquine
resistant (CQR) ...
Synthesis and in vitro biological evaluation of aminoacridines and artemisinin-acridine hybrids
(Elsevier, 2014)
During this study, 9-aminoacridine and artemisinin–acridine hybrid compounds were synthesized and the in vitro for antimalarial activity against both the chloroquine sensitive but also gametocytocidal strain (NF54), and ...
Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria
(Wiley, 2014)
Objectives Mefloquine (MQ) is an antimalarial drug with high efficacy, often
used in the treatment and chemoprophylaxis of malaria. However, it has low solubility
in water, a long elimination half-life (4 days), and is ...
Trends in malaria admissions at the Mbakong Health Centre of the North West Region of Cameroon: a retrospective study
(BioMed Central, 2014)
Background: Malaria is the leading cause of death worldwide. It is urgent to assess the impact of interventions and
scaled-up control efforts. Despite reported reduction in malaria prevalence in Africa, the trends in ...