Browsing Faculty of Natural and Agricultural Sciences by Author "10056173 - Malan, Nicolaas Theodor"
Now showing items 1-20 of 23
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8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA study
Mels, C.M.C.; Schutte, A.E.; Schutte, R.; Pretorius, P.J.; Smith, W.; Huisman, H.W.; Van der Westhuizen, F.H.; Fourie, C.M.T.; Van Rooyen, J.M.; Kruger, R.; Louw, R.; Malan, N.T.; Malan, L. (Taylor & Francis, 2014)Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study ... -
Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study
Kruger, R.; Schutte, R.; Huisman, H.W.; Van Rooyen, J.M.; Malan, N.T.; Fourie, C.M.T.; Louw, R.; Van der Westhuizen, F.H.; Van Deventer, C.A.; Malan, L.; Schutte, A.E. (Springer Nature, 2012)Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory ... -
Blood glutathione and subclinical atherosclerosis in African men: the SABPA study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Szabolcs, Péter; Fourie, Carla M.T.; Van der Westhuizen, Francois H.; Louw, Roan; Botha, Cindy A.; Malan, Leoné (Oxford Univ Press, 2009)Background: Sub-Saharan Africans face an increasing burden of hypertension and related cardiac and cerebrovascular morbidity and mortality, making the identification of factors leading to early vascular abnormalities ... -
Chronic defensiveness and neuroendocrine dysfunction reflect a novel cardiac troponin T cut point: the SABPA study
Malan, Leoné; Hamer, Mark; Von Känel, Roland; Steyn, Hendrik S.; Malan, Nicolaas T. (Elsevier, 2017)Background Sympatho-adrenal responses are activated as an innate defense coping (DefS) mechanism during emotional stress. Whether these sympatho-adrenal responses drive cardiac troponin T (cTnT) increases are unknown. ... -
Cohort profile: sympathetic activity and ambulatory blood pressure in Africans (SABPA) prospective cohort study
Malan, Leoné; Hamer, Mark; Steyn, Hendrik S.; Malan, Nicolaas T.; Frasure-Smith, Nancy (Oxford Univ Press, 2015)Adapting to an over–demanding stressful urban environment may exhaust the psychophysiological resources to cope with these demands, and lead to sympathetic nervous system dysfunction. The evidence that an urban–dwelling ... -
Coping facilitated troponin T increases and hypo-responsivity in the copeptin-HPA-axis during acute mental stress in a black cohort: the SABPA study
Myburgh, Catharina Elizabeth; Malan, Leoné; Möller, Marisa; Steyn, Faans; Malan, Nicolaas Theodor (Elsevier, 2019)Background Defensive coping (DefS) was associated with a vulnerable cardiovascular profile in blacks. The copeptin/vasopressin system is a manifestation of hypothalamic-pituitary-adrenal-axis activity and may act as an ... -
Cortisol: brain-derived neurotrophic factor ratio associated with silent ischaemia in a black male cohort: the SABPA study
Schutte, Christiaan E.; Malan, Leoné; Scheepers, Jacobus D.; Oosthuizen, Woudri; Cockeran, Maricke; Malan, Nicolaas T. (SASA, 2016)Aim: Emotional distress has been associated with cardiovascular disease (CVD) in Africans. Cortisol and brain-derived neurotrophic factor (BDNF), as markers of emotional distress, increase cardiometabolic risk. We therefore ... -
Defensive active coping facilitates chronic hyperglycaemia and endothelial dysfunction in African men: the SABPA study
Malan, L.; Hamer, M.; Steyn, H.S.; Schutte, R.; Smith, W.; Van Rooyen, J.M.; Fourie, C.M.T.; Malan, N.T. (Elsevier, 2013)Background: Dissociation between behavioural defensive active coping (AC) control albeit physiological “loss of control” responses was associated with silent ischaemia and structural wall abnormalities in African men. Whether ... -
Defensive coping facilitated a smaller cortisol-to-estradiol ratio and a higher hypertension risk: the SABPA study
Malan, Leoné; De Kock, Andrea; Hamer, Mark; Cockeran, Marike; Malan, Nicolaas Theodor (Taylor & Francis, 2018)Objectives: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It ... -
Ethnic disparity in defensive coping endothelial responses: the SABPA study
Scheepers, Jacobus De Wet; Malan, Leoné; De Kock, Andrea; Malan, Nicolaas Theodor; Cockeran, Marike; Von Känel, Roland (Elsevier, 2015)Objectives: Defensive coping (DefS) in Blacks has been associated with greater cardiovascular risk than in their White counterparts. We examined associations between endothelial function mental stress responses and markers ... -
Fibrosis and coronary perfusion: a cardiovascular disease risk in an African male cohort: the SABPA study
Jansen van Vuren, Esmé; Malan, Leoné; Cockeran, Marike; Scheepers, Jacobus D.; Oosthuizen, Woudri; Malan, Nicolaas T. (Taylor & Francis, 2016)Low-grade inflammation has been correlated with risk factors of cardiovascular diseases (CVD). Whether the pro-inflammatory and thrombotic ratio (fibrosis) may contribute to CVD is not known. We therefore aimed to assess ... -
Genetic polymorphisms of beta(2)- and beta(3)- adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women
Van Rooyen, J.M.; Pretorius, P.J.; Britz, M.; Huisman, H.W.; Schutte, A.E.; Towers, G.W.; Olckers, A.; Malan, N.T.; Malan, L.; Schutte, R. (Thieme, 2008)Background: Genetic variation in the β2 (ADRB2) and β3 (ADRB3) adrenergic receptor genes are associated with obesity and insulin resistance. To further elucidate the role of these genes in the pathophysiology of obesity ... -
Hypercoagulation and hyperkinetic blood pressure indicative of physiological loss-of-control despite behavioural control in Africans: the SABPA study
Scheepers, Jacobus De Wet; Malan, Leoné; De Kock, Andrea; Malan, Nicolaas Theodor; Cockeran, Marike; Von Känel, Roland (Taylor & Francis, 2016)Objectives: A dissociation between behavioural (in-control) and physiological parameters (indicating loss-of-control) is associated with cardiovascular risk in defensive coping (DefS) Africans. We evaluated relationships ... -
Hyperpulsatile pressure, systemic inflammation and cardiac stress are associated with cardiac wall remodeling in an African male cohort: the SABPA study
Jansen van Vuren, Esmé; Malan, Leoné; Von Känel, Roland; Cockeran, Marike; Malan, Nicolaas Theodor (Nature, 2016)Inflammation may contribute to an increase in cardiac wall stress through pathways related to cardiac remodeling. Cardiac remodeling is characterized by myocyte hypertrophy, myocyte death and modifications of the extracellular ... -
Hypothalamic-pituitary-adrenal-axis dysregulation and double product increases potentiate ischemic heart disease risk in a Black male cohort: the SABPA study
Malan, Leoné; Schutte, Christiaan E.; Malan, Nicolaas T.; Alkerwi, Ala'a; Stranges, Saverio (Springer Nature, 2017)Emotional distress has been associated with a poorer prognosis in myocardial infarction patients. Elevated adrenocorticotrophic hormone (ACTH), lower cortisol, dehydroepiandrosterone sulfate (DHEAS) and cortisol:DHEAS, as ... -
L-Carnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: the SABPA study
Mels, Catharina M. C.; Schutte, Aletta E.; Erasmus, Elardus; Huisman, Hugo W.; Schutte, Rudolph; Fourie, Carla M.T.; Kruger, Ruan; Van Rooyen, Johannes M.; Smith, Wayne; Malan, Nicolaas T.; Malan, Leoné (Springer, 2013)The prevalence of hypertension in sub-Saharan Africa is increasing rapidly, and treatment remains challenging. Although the use of l-carnitine in treatment has received much attention, studies reporting on physiological ... -
Leukocyte telomere length and hemostatic factors in a South African cohort: the SABPA study
Von Känel, R.; Malan, N.T.; Hamer, M.; Van der Westhuizen, F.H.; Malan, L. (Wiley, 2014)Background Incident atherothrombotic disease is predicted by leukocyte telomere length, a marker of biological age, and hemostatic factor levels, indicating a hypercoagulable state. We hypothesized that shorter telomeres ... -
Longitudinal changes of cardiac troponin and inflammation reflect progressive myocyte stretch and likelihood for hypertension in a Black male cohort: the SABPA study
Jansen van Vuren, Esmé; Malan, Leoné; Von Känel, Roland; Lammertyn, Liandi; Cockeran, Marike; Malan, Nicolaas T. (Springer, 2019)Inflammation was cross-sectionally associated with subclinical wall remodeling and hypertension. Whether longitudinal changes (∆) in inflammation, myocyte injury (troponin T), and stretch (N-terminal-pro-B-type natriuretic ... -
Low testosterone and hyperkinetic blood pressure responses in a cohort of South African men: the SABPA study
Malan, Nicolaas T.; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Schutte, Rudolph; Mels, Catharina M.; Steyn, Hendrik S.; Smith, Wayne; Fourie, Carla M.; Glyn, Matthew; Malan, Leoné (Taylor & Francis, 2013)Hypertension (HT) and the metabolic syndrome are major problems in Africa. The role of sex hormones in the cardiovascular profile of black Africans in South Africa has not been studied. Our objective was to study the ... -
The protective role of oestradiol against silent myocardial ischemia and hypertension risk in South African men: the SABPA study
Malan, Nicolaas T.; Von Känel, Roland; Steyn, Hendrik S.; Kruger, Ruan; Malan, Leoné (Elsevier, 2017)Background Oestradiol has a protective effect on coronary artery health in women but the effect it has on men, is controversial. A translational approach was followed to assess whether sex hormone levels are associated ...