Browsing Faculty of Natural and Agricultural Sciences by Author "10059539 - Van Rooyen, Johannes Marthinus"
Now showing items 1-13 of 13
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8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA study
Mels, C.M.C.; Schutte, A.E.; Schutte, R.; Pretorius, P.J.; Smith, W.; Huisman, H.W.; Van der Westhuizen, F.H.; Fourie, C.M.T.; Van Rooyen, J.M.; Kruger, R.; Louw, R.; Malan, N.T.; Malan, L. (Taylor & Francis, 2014)Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study ... -
Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study
Kruger, R.; Schutte, R.; Huisman, H.W.; Van Rooyen, J.M.; Malan, N.T.; Fourie, C.M.T.; Louw, R.; Van der Westhuizen, F.H.; Van Deventer, C.A.; Malan, L.; Schutte, A.E. (Springer Nature, 2012)Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory ... -
Blood glutathione and subclinical atherosclerosis in African men: the SABPA study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Szabolcs, Péter; Fourie, Carla M.T.; Van der Westhuizen, Francois H.; Louw, Roan; Botha, Cindy A.; Malan, Leoné (Oxford Univ Press, 2009)Background: Sub-Saharan Africans face an increasing burden of hypertension and related cardiac and cerebrovascular morbidity and mortality, making the identification of factors leading to early vascular abnormalities ... -
Cardiometabolic markers to identify cardiovascular disease risk in HIV-infected black South Africans
Van Rooyen, J.M.; Fourie, C.M.T.; Steyn, H.S.; Koekemoer, G.; Huisman, H.W.; Schutte, R.; Malan, L.; Glyn, M.; Smith, W.; Mels, C. (SA Medical Association, 2014)BACKGROUND: The prevalence of HIV is the highest in sub-Saharan Africa; South Africa (SA) is one of the most affected countries with the highest number of adults living with HIV infection in the world. Besides the traditional ... -
A comparison of the cardiometabolic profile of black South Africans with suspected non-alcoholic fatty liver disease (NAFLD) and excessive alcohol use
Zatu, Mandlenkosi Caswell; Van Rooyen, Johannes Marthinus; Loots, Du Toit; Greeff, Minrie; Schutte, Aletta Elisabeth (Elsevier, 2015)Excessive alcohol use and non–alcoholic fatty liver disease (NAFLD) are putative cardiovascular disease risk factors. In order to ease the identification of these conditions on primary health care level, we aimed to determine ... -
Defensive active coping facilitates chronic hyperglycaemia and endothelial dysfunction in African men: the SABPA study
Malan, L.; Hamer, M.; Steyn, H.S.; Schutte, R.; Smith, W.; Van Rooyen, J.M.; Fourie, C.M.T.; Malan, N.T. (Elsevier, 2013)Background: Dissociation between behavioural defensive active coping (AC) control albeit physiological “loss of control” responses was associated with silent ischaemia and structural wall abnormalities in African men. Whether ... -
Genetic polymorphisms of beta(2)- and beta(3)- adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women
Van Rooyen, J.M.; Pretorius, P.J.; Britz, M.; Huisman, H.W.; Schutte, A.E.; Towers, G.W.; Olckers, A.; Malan, N.T.; Malan, L.; Schutte, R. (Thieme, 2008)Background: Genetic variation in the β2 (ADRB2) and β3 (ADRB3) adrenergic receptor genes are associated with obesity and insulin resistance. To further elucidate the role of these genes in the pathophysiology of obesity ... -
L-Carnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: the SABPA study
Mels, Catharina M. C.; Schutte, Aletta E.; Erasmus, Elardus; Huisman, Hugo W.; Schutte, Rudolph; Fourie, Carla M.T.; Kruger, Ruan; Van Rooyen, Johannes M.; Smith, Wayne; Malan, Nicolaas T.; Malan, Leoné (Springer, 2013)The prevalence of hypertension in sub-Saharan Africa is increasing rapidly, and treatment remains challenging. Although the use of l-carnitine in treatment has received much attention, studies reporting on physiological ... -
Low testosterone and hyperkinetic blood pressure responses in a cohort of South African men: the SABPA study
Malan, Nicolaas T.; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Schutte, Rudolph; Mels, Catharina M.; Steyn, Hendrik S.; Smith, Wayne; Fourie, Carla M.; Glyn, Matthew; Malan, Leoné (Taylor & Francis, 2013)Hypertension (HT) and the metabolic syndrome are major problems in Africa. The role of sex hormones in the cardiovascular profile of black Africans in South Africa has not been studied. Our objective was to study the ... -
Nocturnal blood pressure, 3–methoxy–4–hydroxyphenylglycol and carotid intima–media thickness: the SABPA study
Uys, Aletta S.; Malan, Leoné; Van Rooyen, Johannes M.; Steyn, Hendrik S.; Ziemssen, Tjalf (Elsevier, 2013)Background: Research demonstrated a significant relationship between elevated nocturnal blood pressure and sym-pathetic hyperactivity. The study aimed to investigate possible associations between norepinephrine ... -
Self-reported alcohol intake is a better estimate of 5-year change in blood pressure than biochemical markers in low resource settings: the PURE study
Zatu, Mandlenkosi C.; Van Rooyen, Johannes M.; Loots, Du Toit; Wentzel-Viljoen, Edelweiss; Greeff, Minrie; Schutte, Aletta E. (Wolters Kluwer, 2014)Background: Despite criticism of self-reported alcohol intake, it is a valuable tool to screen for alcohol abuse as a risk factor for cardiovascular disease. We aimed to compare various self-reported estimates of alcohol ... -
A significant decline in IGF-I may predispose young Africans to subsequent cardiometabolic vulnerability
Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Leoné; Malan, Nicolaas T.; Fourie, Catharina M.T.; Louw, Roan; Van der Westhuizen, Francois H.; Schutte, Rudolph (Oxford Univ Press, 2010)Objectives: Low serum IGF-I is an independent risk factor for diabetes and cardiovascular disease. These noncommunicable diseases are extremely common in urban black South Africans, but their IGF-I concentration is unknown. ... -
Silent ischemia is associated with subclinical atherosclerosis in African males: the sympathetic activity and ambulatory blood pressure in Africans study
Griffiths, Madelein E.; Malan, Leoné; Van Rooyen, Johannes M.; Koekemoer, Gerhard; Vorster, Chris B. (Taylor & Francis, 2012)Silent myocardial ischemia is a predictor of subclinical atherosclerosis driven by increased cardiovascular risk markers, although still unknown in Africans. The aim of this study was to assess if cardiovascular risk markers ...