Browsing Faculty of Natural and Agricultural Sciences by Author "Ikenaka, Yoshinori"
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Accumulation of heavy metals and metalloid in foodstuffs from agricultural soils around Tarkwa area in Ghana, and associated human health risks
Bortey-Sam, Nesta; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Akoto, Osei; Fobil, Julius N. (MDPI, 2015)This study was carried out to assess the extent of heavy metals and metalloid accumulation from agricultural soils to foodstuffs (viz, M. esculenta (cassava) and Musa paradisiaca (plantain)) around thirteen neighboring ... -
Accumulation properties of inorganic mercury and organic mercuryin the red-crownedcrane Grus japonensis in east Hokkaido, Japan
Teraoka, Hiroki; Ikenaka, Yoshinori; Okamoto, Erika; Kudo, Moe; Nakayama, Shouta M.M. (Elsevier, 2015)The red-crowned (Japanese) crane Grus japonensis is native to east Hokkaido, Japan, in contrast to the East Asia mainland. Previously, we reported that red-crowned cranes in Hokkaido were highly contaminated with mercury ... -
Acute exposure to environmentally relevant lead levels induces oxidative stress and neurobehavioral alterations in larval zebrafish (Danio rerio)
Kataba, Andrew; Botha, Tarryn L.; Ikenaka, Yoshinori; Wepener, Victor; Nakayama, Shouta M.M. (Elsevier, 2020)The ubiquitous contamination of environmental lead (Pb) remains a worldwide threat. Improper Pb mine waste disposal from an abandoned lead-zinc mine has recently unearthed widespread Pb poisoning in children in Kabwe Zambia. ... -
Application of a Sediment Quality Index for the assessment and monitoring of metals and organochlorines in a premier conservation area
Gerber, Ruan; Smit, Nico J.; Ikenaka, Yoshinori; Wepener, Victor; Van Vuren, Johan H.J. (Springer, 2015)The physical and chemical characteristics of surface sediments from a leading conservation area, namely the Kruger National Park, were determined in order to identify potential stressors in the systems that may contribute ... -
Are red gourami (Colisa labiosa) low xenobiotic metabolizers? Elucidation of in vivo pharmacokinetics of pyrene as a model substrate
Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Oguri, Mami; Mizukawa, Hazuki; Saengtienchai, Aksorn (Elsevier, 2015)Red gourami (Colisa labiosa) have previously been shown to have low levels of pyrene-metabolizing activity. In this study, other pharmacokinetic factors of pyrene in C. labiosawere compared to those in Japanese medaka ... -
Bioimaging of Pb and STIM1 in mice liver, kidney and brain using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and immunohistochemistry
Togoa, Masao; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Mizukawa, Hazuki; Makino, Yoshiki (Elsevier, 2020)Lead (Pb) pollution is one of the most serious environmental problems and has attracted worldwide attention. Pb causes hematological, central nervous system, as well as renal toxicity, and so on. Although many investigations ... -
Characterization and imaging of lead distribution in bones of lead-exposed birds by ICP-MS and LA-ICP-MS
Ishii, Chihiro; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Kataba, Andrew; Saito, Keisuke (Elsevier, 2018)Lead (Pb) poisoning in raptors and water birds is a serious problem in many countries. However, only a small fraction of Pb poisoning has been detected in birds. Bone specimens may be useful indices of Pb exposure because ... -
Characterization and tissue distribution of conjugated metabolites of pyrene in the rat
Saengtienchai, Aksorn; Ikenaka, Yoshinori; Darwish, Wageh Sobhy; Nakayama, Shouta M.M.; Mizukawa, Hazuki (Japanese Society of Veterinary Science, 2015)Pyrene (PY) is a polycyclic aromatic hydrocarbon (PAH) that is often used as a biomarker for human and wildlife exposure to PAHs. As the metabolites of PAHs, similar to their parent compounds, pose public health risks, ... -
Comparison of two reducing agents dithiothreitol and tris(3-hydroxypropyl)phosphine for in vitro kinetic assay of vitamin K epoxide reductase
Takeda, Kazuki; Ikenaka, Yoshinori; Morita, Ayuka; Nakayama, Shouta M.M.; Ishizuka, Mayumi (Elsevier, 2020)Vitamin K epoxide reductase (VKOR) is a target enzyme for anticoagulants, such as warfarin, that are used as medicines or rodenticides. Assessing VKOR activity is required to ensure the proper usage of these drugs. ... -
Current situation regarding lead exposure in birds in Japan (2015–2018); lead exposure is still occurring
Ishii, Chihiro; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Kuritani, Takeshi; Nakagawa, Mitsuhiro (The Japanese Society of Veterinary Science, 2020)Birds of a number of species have died as a result of lead (Pb) poisoning, including many Steller’s sea eagles (Haliaeetus pelagicus) and white-tailed sea eagles (Haliaeetus albicilla) in Hokkaido, the northernmost island ... -
Cytochrome P450-mediated warfarin metabolic ability is not a critical determinant of warfarin sensitivity in avian species: in vitro assays in several birds and in vivo assays in chicken
Watanabe, Kensuke P.; Ikenaka, Yoshinori; Kawata, Minami; Nakayama, Shouta M.M.; Ishii, Chihiro (Wiley, 2015)Coumarin-derivative anticoagulant rodenticides used for rodent control are posing a serious risk to wild bird populations. For warfarin, a classic coumarin derivative, chickens have a high median lethal dose (LD50), whereas ... -
Dichlorodiphenyltrichloroethane (DDT) levels in rat livers collected from a malaria vector control region
Motohira, Kodai; Ikenaka, Yoshinori; Wepener, Victor; Smit, Nico J.; Van Vuren, Johan H.J. (Japanese Society of Veterinary Science, 2019)Dichlorodiphenyltrichloroethane (DDT) is an organochlorine insecticide that has been used for indoor residual spraying for the control of mosquito-borne diseases including malaria. However, due to its toxicity and ... -
Factors associated with lead (Pb) exposure on dogs around a Pb mining area, Kabwe, Zambia
Toyomaki, Haruya; Ikenaka, Yoshinori; Yabe, John; Nakayama, Shouta M.M.; Yohannes, Yared B. (Elsevier, 2020)Lead (Pb)-poisoning is a serious public health concern and dogs have been useful as a sentinel-animal for Pb exposure of humans. In the present study, the blood Pb concentrations (BLC), isotope ratios (208 Pb/206 Pb and ... -
Interspecies differences in cytochrome P450-mediated metabolism of neonicotinoids among cats, dogs, rats, and humans
Khidkhan, Kraisiri; Ikenaka, Yoshinori; Ichise, Takahiro; Nakayama, Shouta M.M.; Mizukawa, Hazuki (Elsevier, 2020)Neonicotinoid insecticides are used for agricultural and non-agricultural purposes worldwide. Pets are directly exposed to neonicotinoids in veterinary products and through environmental contamination. Cytochrome P450 (CYP) ... -
Investigation of mRNA expression changes associated with field exposure to DDTs in chickens from KwaZulu-Natal, South Africa
Thompson, Lesa A.; Ikenaka, Yoshinori; Van Vuren, Johan J.; Wepener, Victor; Smit, Nico J. (PLoS, 2018)The objective of this study was to identify potential mRNA expression changes in chicken livers associated with environmental exposure to dichloro-diphenyl-trichloroethane (DDT) and its metabolites (DDTs). In particular, ... -
Metal extent in blood of livestock from Dandora dumping site, Kenya: source identification of Pb exposure by stable isotope analysis
Nakata, Hokuto; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Mizukawa, Hazuki; Ishii, Chihiro (Elsevier, 2015)Nairobi city in Kenya produces 2000 tons/day of garbage, and most of it is dumped onto the Dandora dumping site, home to a quarter-million residents. This study was conducted (1) to assess the contamination levels of nine ... -
Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice
Ohno, Shuji; Ikenaka, Yoshinori; Onaru, Kanoko; Kubo, Shizuka; Sakata, Nanami (Elsevier, 2020)Neonicotinoids (NNs), a widely used class of systemic pesticides, are regarded as exhibiting selective toxicity in insects. However, NNs are suspected of exerting adverse effects on mammals as well, including humans. To ... -
Sex-specific behavioral effects of acute exposure to the neonicotinoid clothianidin in mice
Kubo, Shizuka; Hirano, Tetsushi; Miyata, Yuka; Ohno, Shuji; Onaru, Kanoko; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Ishizuka, Mayumi; Mantani, Youhei; Yokoyama, Toshifumi; Hoshi, Nobuhiko (Elsevier Inc, 2022)Although neonicotinoids are among the major classes of pesticides that affect mammalian nervous systems, little is known about sex differences in their effects. This study aimed to examine whether the neurobehavioral ... -
Trophic transfer of pollutants within two intertidal rocky shore ecosystems in different biogeographic regions of South Africa
Erasmus, Anja; Ikenaka, Yoshinori; Smit, Nico J.; Wepener, Victor; Nakayama, Shouta M.M. (Elsevier, 2020)Tsitsikamma and Sheffield Beach are two relatively pristine sites along the South African east coast representing warm temperate and subtropical biogeographic rocky shore intertidal ecosystems, respectively. Stable isotopes ...