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dc.contributor.authorJoubert, Jacques
dc.contributor.authorPetzer, Jacobus P.
dc.contributor.authorRepsold, Benjamin P.
dc.contributor.authorPrins, Louis H.A.
dc.contributor.authorMalan, Sarel F.
dc.date.accessioned2016-10-31T13:05:32Z
dc.date.available2016-10-31T13:05:32Z
dc.date.issued2015
dc.identifier.citationJoubert, J. et al. 2015. Multifunctional enzyme inhibition for neuroprotection: a focus on MAO, NOS, and AChE inhibitors. (In Atta-ur-Rahman & Choudhary, M.I., eds. Drug design and discovery in Alzheimer's disease. Ch. 5. p. 291-365.) [https://doi.org/10.1016/B978-0-12-803959-5.50005-2]en_US
dc.identifier.isbn978-0-12-803959-5
dc.identifier.urihttp://hdl.handle.net/10394/19255
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/B9780128039595500052
dc.identifier.urihttps://doi.org/10.1016/B978-0-12-803959-5.50005-2
dc.description.abstractNeurodegenerative disorders are known to be multifactorial in nature and current research focus has moved from a ‘one-drug-one-target approach’ to that of drugs which are able to act at various relevant biological targets. These drugs are designed to address more than one etiological target, thereby increasing therapeutic effect and patient compliance and may lower the likelihood of encountering unwanted side-effects. Monoamine oxidase (MAO), nitric oxide synthase (NOS), and acetylcholinesterase (AChE) are enzymes that have long been associated as potential targets for neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. The selective inhibition of the abovementioned enzymes and other relevant CNS targets may provide promising strategies in the development of multifunctional neuroprotective therapeutic agents for the treatment/prevention of neurodegenerative disordersen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAlzheimer’s and Parkinson’s diseaseen_US
dc.subjectDrug designen_US
dc.subjectMonoamine oxidaseen_US
dc.subjectMulti-target-directed ligandsen_US
dc.subjectNeurodegenerative disordersen_US
dc.subjectNitric oxide synthaseen_US
dc.titleMultifunctional enzyme inhibition for neuroprotection: a focus on MAO, NOS, and AChE inhibitorsen_US
dc.typeBook chapteren_US
dc.contributor.researchID10727388 - Petzer, Jacobus Petrus
dc.contributor.researchID12534005 - Repsold, Benjamin Petrus


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